node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
X1WHF1_DANRE | atm | ENSDARP00000129663 | ENSDARP00000015167 | Histone H2B; Belongs to the histone H2B family. | Non-specific serine/threonine protein kinase. | 0.637 |
X1WHF1_DANRE | chek2 | ENSDARP00000129663 | ENSDARP00000036490 | Histone H2B; Belongs to the histone H2B family. | Checkpoint kinase 2. | 0.601 |
X1WHF1_DANRE | h2ax | ENSDARP00000129663 | ENSDARP00000040327 | Histone H2B; Belongs to the histone H2B family. | Histone H2AX; Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post- translational modifications of histones, also called histone code, and nucleosome remodeling. Required for checkpoint-mediated arrest of cell cycle progression in response to low dos [...] | 0.865 |
X1WHF1_DANRE | h3f3a-2 | ENSDARP00000129663 | ENSDARP00000089753 | Histone H2B; Belongs to the histone H2B family. | Histone H3.3; Variant histone H3 which replaces conventional H3 in a wide range of nucleosomes in active genes. Constitutes the predominant form of histone H3 in non-dividing cells and is incorporated into chromatin independently of DNA synthesis. Deposited at sites of nucleosomal displacement throughout transcribed genes, suggesting that it represents an epigenetic imprint of transcriptionally active chromatin. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in [...] | 0.968 |
X1WHF1_DANRE | hist2h2l | ENSDARP00000129663 | ENSDARP00000055912 | Histone H2B; Belongs to the histone H2B family. | Histone H2B 3; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. | 0.405 |
X1WHF1_DANRE | mdc1 | ENSDARP00000129663 | ENSDARP00000106038 | Histone H2B; Belongs to the histone H2B family. | Mediator of DNA damage checkpoint 1. | 0.605 |
X1WHF1_DANRE | rnf168 | ENSDARP00000129663 | ENSDARP00000154968 | Histone H2B; Belongs to the histone H2B family. | E3 ubiquitin-protein ligase rnf168; E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with ube2n/ubc13 to amplify the rnf8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and ubiquitinates histone H2A and H2AX, leading to amplify the rnf8-dependent H2A ubiquitination and promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recrui [...] | 0.622 |
X1WHF1_DANRE | xrcc6 | ENSDARP00000129663 | ENSDARP00000096636 | Histone H2B; Belongs to the histone H2B family. | X-ray repair-complementing defective repair in Chinese hamster cells 6. | 0.673 |
X1WHF1_DANRE | zgc:113983 | ENSDARP00000129663 | ENSDARP00000084277 | Histone H2B; Belongs to the histone H2B family. | Histone H3.2; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. | 0.961 |
atm | X1WHF1_DANRE | ENSDARP00000015167 | ENSDARP00000129663 | Non-specific serine/threonine protein kinase. | Histone H2B; Belongs to the histone H2B family. | 0.637 |
atm | chek2 | ENSDARP00000015167 | ENSDARP00000036490 | Non-specific serine/threonine protein kinase. | Checkpoint kinase 2. | 0.999 |
atm | h2ax | ENSDARP00000015167 | ENSDARP00000040327 | Non-specific serine/threonine protein kinase. | Histone H2AX; Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post- translational modifications of histones, also called histone code, and nucleosome remodeling. Required for checkpoint-mediated arrest of cell cycle progression in response to low dos [...] | 0.850 |
atm | h3f3a-2 | ENSDARP00000015167 | ENSDARP00000089753 | Non-specific serine/threonine protein kinase. | Histone H3.3; Variant histone H3 which replaces conventional H3 in a wide range of nucleosomes in active genes. Constitutes the predominant form of histone H3 in non-dividing cells and is incorporated into chromatin independently of DNA synthesis. Deposited at sites of nucleosomal displacement throughout transcribed genes, suggesting that it represents an epigenetic imprint of transcriptionally active chromatin. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in [...] | 0.528 |
atm | hist2h2l | ENSDARP00000015167 | ENSDARP00000055912 | Non-specific serine/threonine protein kinase. | Histone H2B 3; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. | 0.636 |
atm | mdc1 | ENSDARP00000015167 | ENSDARP00000106038 | Non-specific serine/threonine protein kinase. | Mediator of DNA damage checkpoint 1. | 0.984 |
atm | rnf168 | ENSDARP00000015167 | ENSDARP00000154968 | Non-specific serine/threonine protein kinase. | E3 ubiquitin-protein ligase rnf168; E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with ube2n/ubc13 to amplify the rnf8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and ubiquitinates histone H2A and H2AX, leading to amplify the rnf8-dependent H2A ubiquitination and promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recrui [...] | 0.851 |
atm | xrcc6 | ENSDARP00000015167 | ENSDARP00000096636 | Non-specific serine/threonine protein kinase. | X-ray repair-complementing defective repair in Chinese hamster cells 6. | 0.977 |
atm | zgc:113983 | ENSDARP00000015167 | ENSDARP00000084277 | Non-specific serine/threonine protein kinase. | Histone H3.2; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. | 0.528 |
chek2 | X1WHF1_DANRE | ENSDARP00000036490 | ENSDARP00000129663 | Checkpoint kinase 2. | Histone H2B; Belongs to the histone H2B family. | 0.601 |
chek2 | atm | ENSDARP00000036490 | ENSDARP00000015167 | Checkpoint kinase 2. | Non-specific serine/threonine protein kinase. | 0.999 |