Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
rhoaaRho-related GTP-binding protein RhoA-A; Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. (193 aa)    
Predicted Functional Partners:
rock2a
Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity.
    
 0.970
arhgef2
Rho/rac guanine nucleotide exchange factor (GEF) 2.
   
 0.957
arhgef11
Rho guanine nucleotide exchange factor (GEF) 11.
   
 0.948
arhgdig
Rho GDP dissociation inhibitor (GDI) gamma.
   
 0.945
arhgap5
Rho GTPase-activating protein 5.
    
 0.941
arhgap35a
Rho GTPase-activating protein 35a.
    
 0.941
rock1
Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity.
    
 0.937
arhgef1a
Rho guanine nucleotide exchange factor (GEF) 1a.
    
 0.930
diaph2
Diaphanous-related formin 2.
   
 0.917
daam2
Dishevelled-associated activator of morphogenesis 2.
    
 0.908
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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