STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ccdc170Coiled-coil domain-containing 170. (252 aa)    
Predicted Functional Partners:
dmap1
DNA methyltransferase 1-associated protein 1.
   
 
 0.862
ruvbl2
RuvB-like 2; Has double-stranded DNA-stimulated ATPase activity. Has ATP-dependent DNA helicase (5' to 3') activity suggesting a role in nuclear processes such as recombination and transcription (By similarity). Represses gene activation mediated by beta-catenin. Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome- activated ATPase activity and catalyzes ATP-dependent nucleosome sliding (By similarity). Involved in the endoplasmic reticulum (ER)- associated degradation (ERAD) pathway where it negatively regulates expression of ER stress [...]
   
 
 0.861
ak8
Adenylate kinase 8; Nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Has highest activity toward AMP, and weaker activity toward dAMP, CMP and dCMP. Also displays broad nucleoside diphosphate kinase activity.
   
 
 0.857
ruvbl1
RuvB-like 1; Has single-stranded DNA-stimulated ATPase and ATP-dependent DNA helicase (3' to 5') activity suggesting a role in nuclear processes such as recombination and transcription (By similarity). Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP- dependent nucleosome sliding (By similarity). May act as a negative regulator of embryonic heart growth. Belongs to the RuvB family.
    
 
 0.854
cfap100
Cilia and flagella-associated protein 100.
   
  
 0.804
spa17
Sperm autoantigenic protein 17.
      
 0.802
actr6
Actin-related protein 6; Belongs to the actin family.
    
 
 0.801
COLEC10
Si:ch211-93i7.4.
   
 
 0.754
ccdc113
Coiled-coil domain-containing protein 113; May be involved in primary cilium formation.
   
  
 0.750
h2az2a
Histone H2A.V; Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post- translational modifications of histones, also called histone code, and nucleosome remodeling. May be involved in the formation of constitutive heterochromatin. May be required for c [...]
    
 
 0.746
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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