STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
rfx3Transcription factor RFX3; Transcription factor required for ciliogenesis and islet cell differentiation during endocrine pancreas development; Belongs to the RFX family. (765 aa)    
Predicted Functional Partners:
foxj1a
Forkhead box protein J1-A; Key transcription factor required for motile ciliogenesis. Activates genes essential for motile cilia formation and function. Its activity is sufficient for ectopic development of cilia that resemble motile cilia.
    
 
 0.902
mcidas
Uncharacterized protein.
      
 0.832
atr
ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family.
    
 
 0.770
spag6
Sperm-associated antigen 6.
      
 0.744
pcsk6
Proprotein convertase subtilisin/kexin type 6.
      
 0.660
dync2li1
Cytoplasmic dynein 2 light intermediate chain 1; Required for correct intraflagellar transport (IFT), the bi- directional movement of particles required for the assembly, maintenance and functioning of primary cilia. Involved in the regulation of ciliary length.
      
 0.652
dpcd
Protein DPCD; Belongs to the DPCD family.
      
 0.651
chek2
Checkpoint kinase 2.
    
 
 0.601
foxj1b
Forkhead box protein J1-B; Key transcription factor required for motile ciliogenesis. Activates genes essential for motile cilia formation and function. Belongs to the FOXJ1 family.
    
 
 0.585
ccno
CYCLIN domain-containing protein; Belongs to the cyclin family.
   
  
 0.558
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.