Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
rfx3Transcription factor RFX3; Transcription factor required for ciliogenesis and islet cell differentiation during endocrine pancreas development; Belongs to the RFX family. (765 aa)    
Predicted Functional Partners:
foxj1a
Forkhead box protein J1-A; Key transcription factor required for motile ciliogenesis. Activates genes essential for motile cilia formation and function. Its activity is sufficient for ectopic development of cilia that resemble motile cilia.
    
 
 0.940
mcidas
Uncharacterized protein.
      
 0.780
myb
V-myb avian myeloblastosis viral oncogene homolog.
    
 
 0.755
chek2
Checkpoint kinase 2.
    
 0.751
mybl2a
V-myb avian myeloblastosis viral oncogene homolog-like 2a.
    
 
 0.703
spag6
Sperm-associated antigen 6.
    
 
 0.683
foxj1b
Forkhead box protein J1-B; Key transcription factor required for motile ciliogenesis. Activates genes essential for motile cilia formation and function. Belongs to the FOXJ1 family.
    
 
 0.681
atr
ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family.
    
 
 0.668
rfxap
Regulatory factor X-associated protein.
    
 0.658
dync2li1
Cytoplasmic dynein 2 light intermediate chain 1; Required for correct intraflagellar transport (IFT), the bi- directional movement of particles required for the assembly, maintenance and functioning of primary cilia. Involved in the regulation of ciliary length.
      
 0.650
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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