node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
atg10 | atg12 | ENSDARP00000140378 | ENSDARP00000092078 | ATG10 autophagy-related 10 homolog (S. cerevisiae). | Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family. | 0.998 |
atg10 | atg16l1 | ENSDARP00000140378 | ENSDARP00000130065 | ATG10 autophagy-related 10 homolog (S. cerevisiae). | ATG16 autophagy-related 16-like 1 (S. cerevisiae). | 0.909 |
atg10 | atg16l2 | ENSDARP00000140378 | ENSDARP00000090294 | ATG10 autophagy-related 10 homolog (S. cerevisiae). | ATG16 autophagy-related 16-like 2 (S. cerevisiae). | 0.684 |
atg10 | atg3 | ENSDARP00000140378 | ENSDARP00000041303 | ATG10 autophagy-related 10 homolog (S. cerevisiae). | Ubiquitin-like-conjugating enzyme ATG3; E2 conjugating enzyme required for the cytoplasm to vacuole transport (Cvt), autophagy, and mitochondrial homeostasis. Responsible for the E2-like covalent binding of phosphatidylethanolamine to the C- terminal Gly of atg8-like proteins (gabarap, gabarapl1, gabarapl2 or map1lc3a). The atg12-atg5 conjugate plays a role of an E3 and promotes the transfer of atg8-like proteins from atg3 to phosphatidylethanolamine (PE). This step is required for the membrane association of atg8-like proteins. The formation of the atg8- phosphatidylethanolamine conju [...] | 0.985 |
atg10 | atg5 | ENSDARP00000140378 | ENSDARP00000124077 | ATG10 autophagy-related 10 homolog (S. cerevisiae). | Autophagy protein 5; Involved in autophagic vesicle formation. | 0.985 |
atg10 | atg7 | ENSDARP00000140378 | ENSDARP00000134373 | ATG10 autophagy-related 10 homolog (S. cerevisiae). | Ubiquitin-like modifier-activating enzyme ATG7; E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 as well as the ATG8 family proteins for their conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Required for autophagic death induced by caspase-8 inhibition. Required for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria [...] | 0.994 |
atg10 | becn1 | ENSDARP00000140378 | ENSDARP00000100986 | ATG10 autophagy-related 10 homolog (S. cerevisiae). | Beclin-1; Plays a central role in autophagy. Acts as core subunit of different PI3K complex forms that mediate formation of phosphatidylinositol 3- phosphate and are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis (By similarity). Involved in regulation of degradative endocytic trafficking and required for the abcission step in cytokinesis, probably in the context of PI3KC3-C2 (By similarity). Essential for the formation of PI3KC3-C2 but not PI3KC3-C1 P [...] | 0.918 |
atg10 | gabarapa | ENSDARP00000140378 | ENSDARP00000051546 | ATG10 autophagy-related 10 homolog (S. cerevisiae). | GABA(A) receptor-associated protein a. | 0.875 |
atg10 | gabarapb | ENSDARP00000140378 | ENSDARP00000068351 | ATG10 autophagy-related 10 homolog (S. cerevisiae). | GABA(A) receptor-associated protein b. | 0.496 |
atg10 | gabarapl2 | ENSDARP00000140378 | ENSDARP00000039056 | ATG10 autophagy-related 10 homolog (S. cerevisiae). | GABA(A) receptor-associated protein-like 2. | 0.725 |
atg12 | atg10 | ENSDARP00000092078 | ENSDARP00000140378 | Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family. | ATG10 autophagy-related 10 homolog (S. cerevisiae). | 0.998 |
atg12 | atg16l1 | ENSDARP00000092078 | ENSDARP00000130065 | Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family. | ATG16 autophagy-related 16-like 1 (S. cerevisiae). | 0.999 |
atg12 | atg16l2 | ENSDARP00000092078 | ENSDARP00000090294 | Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family. | ATG16 autophagy-related 16-like 2 (S. cerevisiae). | 0.990 |
atg12 | atg3 | ENSDARP00000092078 | ENSDARP00000041303 | Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family. | Ubiquitin-like-conjugating enzyme ATG3; E2 conjugating enzyme required for the cytoplasm to vacuole transport (Cvt), autophagy, and mitochondrial homeostasis. Responsible for the E2-like covalent binding of phosphatidylethanolamine to the C- terminal Gly of atg8-like proteins (gabarap, gabarapl1, gabarapl2 or map1lc3a). The atg12-atg5 conjugate plays a role of an E3 and promotes the transfer of atg8-like proteins from atg3 to phosphatidylethanolamine (PE). This step is required for the membrane association of atg8-like proteins. The formation of the atg8- phosphatidylethanolamine conju [...] | 0.999 |
atg12 | atg5 | ENSDARP00000092078 | ENSDARP00000124077 | Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family. | Autophagy protein 5; Involved in autophagic vesicle formation. | 0.999 |
atg12 | atg7 | ENSDARP00000092078 | ENSDARP00000134373 | Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family. | Ubiquitin-like modifier-activating enzyme ATG7; E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 as well as the ATG8 family proteins for their conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Required for autophagic death induced by caspase-8 inhibition. Required for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria [...] | 0.999 |
atg12 | becn1 | ENSDARP00000092078 | ENSDARP00000100986 | Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family. | Beclin-1; Plays a central role in autophagy. Acts as core subunit of different PI3K complex forms that mediate formation of phosphatidylinositol 3- phosphate and are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis (By similarity). Involved in regulation of degradative endocytic trafficking and required for the abcission step in cytokinesis, probably in the context of PI3KC3-C2 (By similarity). Essential for the formation of PI3KC3-C2 but not PI3KC3-C1 P [...] | 0.994 |
atg12 | gabarapa | ENSDARP00000092078 | ENSDARP00000051546 | Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family. | GABA(A) receptor-associated protein a. | 0.993 |
atg12 | gabarapb | ENSDARP00000092078 | ENSDARP00000068351 | Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family. | GABA(A) receptor-associated protein b. | 0.982 |
atg12 | gabarapl2 | ENSDARP00000092078 | ENSDARP00000039056 | Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family. | GABA(A) receptor-associated protein-like 2. | 0.987 |