Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
crygn2Gamma-crystallin N-B; Crystallins are the dominant structural components of the vertebrate eye lens. (206 aa)    
Predicted Functional Partners:
mtor
Serine/threonine-protein kinase TOR; Belongs to the PI3/PI4-kinase family.
    
 0.915
rptor
Regulatory-associated protein of MTOR, complex 1.
    
 0.901
akt1s1
AKT1 substrate 1 (proline-rich).
    
 0.864
tsc1a
TSC complex subunit 1a.
   
 0.849
tsc1b
TSC complex subunit 1b.
   
 0.849
tsc2
TSC complex subunit 2.
    
 0.847
ENSDARP00000153406
DUF3384 domain-containing protein.
    
 0.847
mlst8
Target of rapamycin complex subunit lst8.
    
 0.825
zgc:73226
Zgc:73226.
    
 0.792
tbc1d7
TBC1 domain family member 7; Component of the TSC-TBC complex, that contains tbc1d7 in addition to the TSC1-TSC2 complex and consists of the functional complex possessing GTPase-activating protein (GAP) activity toward rheb in response to alterations in specific cellular growth conditions. The small GTPase rheb is a direct activator of the protein kinase activity of mTORC1 and the TSC-TBC complex acts as a negative regulator of mTORC1 signaling cascade by acting as a GAP for RHEB (By similarity).
     
 0.772
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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