Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
prrx1aPaired-related homeobox 1a. (245 aa)    
Predicted Functional Partners:
twist1a
Twist family bHLH transcription factor 1a.
   
 
 0.821
zfhx3
Zinc finger homeobox 3.
      
 0.780
tgfb3
Transforming growth factor beta; Belongs to the TGF-beta family.
   
 
 0.712
hand2
Heart- and neural crest derivatives-expressed protein 2; Essential for myocardial and pectoral fin differentiation, patterning and morphogenesis.
   
 
 0.697
arxa
Aristaless-related homeobox protein; Appears to be indispensable for the central nervous system development. May have a role in the neuronal differentiation of the ganglionic eminence and ventral thalamus. May also be involved in axonal guidance in the floor plate; Belongs to the paired homeobox family. Bicoid subfamily.
   
 
  0.691
arxb
Aristaless-related homeobox b.
   
 
  0.691
col6a2
Collagen, type VI, alpha 2.
   
  
 0.655
col6a1
Collagen, type VI, alpha 1.
   
  
 0.639
mak
Male germ cell-associated kinase.
   
    0.632
he1.3
Metalloendopeptidase.
   
    0.632
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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