Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
flvcr1FLVCR heme transporter 1. (527 aa)    
Predicted Functional Partners:
slc46a1
Proton-coupled folate transporter; Has been shown to act both as an intestinal proton-coupled high-affinity folate transporter and as an intestinal heme transporter which mediates heme uptake from the gut lumen into duodenal epithelial cells. Shows a higher affinity for folate than heme (By similarity). Belongs to the major facilitator superfamily. SLC46A family.
      
 0.734
cpox
Coproporphyrinogen oxidase.
      
 0.607
steap3
STEAP family member 3, metalloreductase.
      
 0.600
abcb10
ATP-binding cassette, sub-family B (MDR/TAP), member 10.
      
 0.597
abcb6a
ATP-binding cassette, sub-family B (MDR/TAP), member 6a.
      
 0.597
fech
Ferrochelatase; Catalyzes the ferrous insertion into protoporphyrin IX.
      
 0.596
hpxb
Hemopexin b.
      
 0.594
alas1
5-aminolevulinate synthase.
      
 0.572
hpxa
Hemopexin; Binds heme and transports it to the liver for breakdown and iron recovery, after which the free hemopexin returns to the circulation.
      
 0.571
mfsd8
Major facilitator superfamily domain-containing protein 8; May be a carrier that transport small solutes by using chemiosmotic ion gradients; Belongs to the major facilitator superfamily.
      
 0.569
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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