Nodes:
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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[Homology]
Score
pfkfb36-phosphofructo-2-kinase/fructose-2, 6-biphosphatase 3. (536 aa)    
Predicted Functional Partners:
hk2
Hexokinase 2.
   
 0.964
hkdc1
Hexokinase domain-containing 1.
   
 0.954
mpi
Mannose-6-phosphate isomerase.
  
 
 0.949
hk1
Hexokinase 1.
   
 0.917
fbp2
Fructose-1,6-bisphosphatase 2; Belongs to the FBPase class 1 family.
   
 
 0.907
fbp1b
Fructose-1,6-bisphosphatase 1b; Belongs to the FBPase class 1 family.
   
 
 0.907
fbp1a
Fructose-1,6-bisphosphatase 1a; Belongs to the FBPase class 1 family.
   
 
 0.894
pfkpa
ATP-dependent 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily.
    
 0.888
pfkpb
ATP-dependent 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily.
    
 0.888
tigarb
Fructose-2,6-bisphosphatase TIGAR B; Fructose-bisphosphatase hydrolyzing fructose-2,6-bisphosphate as well as fructose-1,6-bisphosphate. Acts as a negative regulator of glycolysis by lowering intracellular levels of fructose-2,6- bisphosphate in a p53/TP53-dependent manner, resulting in the pentose phosphate pathway (PPP) activation and NADPH production. Contributes to the generation of reduced glutathione to cause a decrease in intracellular reactive oxygen species (ROS) content, correlating with its ability to protect cells from oxidative or metabolic stress-induced cell death. May p [...]
    
 0.853
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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