STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
parpbpPCNA-interacting partner; Required to suppress inappropriate homologous recombination, thereby playing a central role DNA repair and in the maintenance of genomic stability; Belongs to the PARI family. (579 aa)    
Predicted Functional Partners:
cenpi
Centromere protein I.
   
  
 0.836
pif1
ATP-dependent DNA helicase PIF1; DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability.
   
  
 0.800
ckap2l
Cytoskeleton-associated protein 2-like.
   
 
 0.752
cyp2x12-2
Cytochrome P450, family 2, subfamily X, polypeptide 12; Belongs to the cytochrome P450 family.
   
  
 0.748
cyp2x12
Cytochrome P450, family 2, subfamily X, polypeptide 12; Belongs to the cytochrome P450 family.
   
  
 0.748
cenpk
Centromere protein K.
   
  
 0.737
kif4
Kinesin family member 4; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.
   
  
 0.736
cenpp
Centromere protein P; Probable component of a centromeric complex involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation; Belongs to the CENP-P/CTF19 family.
   
  
 0.724
kntc1
Kinetochore-associated 1.
   
  
 0.720
primpol
DNA-directed primase/polymerase protein; DNA primase and DNA polymerase required to tolerate replication-stalling lesions by bypassing them. Required to facilitate mitochondrial and nuclear replication fork progression by initiating de novo DNA synthesis using dNTPs and acting as an error-prone DNA polymerase able to bypass certain DNA lesions (By similarity). Shows a high capacity to tolerate DNA damage lesions such as 8oxoG and abasic sites in DNA (By similarity). Provides different translesion synthesis alternatives when DNA replication is stalled: able to synthesize DNA primers dow [...]
   
 
 0.715
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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