Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
krt95Kertain 95; Belongs to the intermediate filament family. (425 aa)    
Predicted Functional Partners:
slc38a8b
Solute carrier family 38 member 8b.
      
 0.594
zgc:86896
Actin-related protein 2/3 complex subunit; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.
     
 0.537
zgc:158846
Zgc:158846; Belongs to the intermediate filament family.
  
 
0.529
krt5
Keratin 5; Belongs to the intermediate filament family.
    
  0.523
thyn1
Thymocyte nuclear protein 1; Specifically binds 5-hydroxymethylcytosine (5hmC), suggesting that it acts as a specific reader of 5hmC.
      
 0.502
tpcn2
Two pore calcium channel protein 2; Nicotinic acid adenine dinucleotide phosphate (NAADP) receptor that may function as one of the major voltage-gated Ca(2+) channels (VDCC) across the lysosomal membrane. May be involved in smooth muscle contraction (By similarity).
    
 
 0.502
adgrf6-2
Adhesion G protein-coupled receptor F6; Belongs to the G-protein coupled receptor 2 family.
      
 0.469
cpsf1
Cleavage and polyadenylation-specific factor 1.
    
  0.429
hephl1a
Hephaestin-like 1a; Belongs to the multicopper oxidase family.
      
 0.427
ftr52p
FinTRIM family, member 52, pseudogene.
    
  0.421
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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