Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
zc3h10Zinc finger CCCH-type-containing 10. (541 aa)    
Predicted Functional Partners:
uhrf1
E3 ubiquitin-protein ligase UHRF1; Multidomain protein that acts as a key epigenetic regulator by bridging DNA methylation and chromatin modification. Specifically recognizes and binds hemimethylated DNA at replication forks via its YDG domain and recruits dnmt1 methyltransferase to ensure faithful propagation of the DNA methylation patterns through DNA replication. In addition to its role in maintenance of DNA methylation, also plays a key role in chromatin modification: through its tudor-like regions and PHD-type zinc fingers, specifically recognizes and binds histone H3 trimethylate [...]
      
 0.750
cdyl
Chromodomain protein, Y-like.
      
 0.746
LOC568375
Pre-miRNA 5'-monophosphate methyltransferase; O-methyltransferase that specifically dimethylates the 5' monophosphate of pre-miRNAs, acting as a negative regulator of miRNA processing. The 5' monophosphate of pre-miRNAs is recognized by dicer1 and is required for pre-miRNAs processing: methylation at this position reduces the processing of pre-miRNAs by dicer1 (By similarity).
   
  
 0.711
huwe1
HECT, UBA and WWE domain-containing E3 ubiquitin protein ligase 1.
      
 0.675
rpl30
Ribosomal protein L30.
   
   0.651
gpatch4
G patch domain-containing 4.
    
   0.651
rras
Related RAS viral (R-ras) oncogene homolog.
      
 0.633
rras2
Related RAS viral (R-ras) oncogene homolog 2.
      
 0.633
rbm39a
RNA-binding motif protein 39a.
   
 
 0.624
rbm39b
RNA-binding motif protein 39b.
   
 
 0.624
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
Server load: low (18%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.