Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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co-expression
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cyp26a1Cytochrome P450 26A1; A cytochrome P450 monooxygenase involved in the metabolism of all-trans retinoic acid (atRA), a signaling molecule that binds to retinoic acid receptors and regulates gene transcription. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase). Catalyzes the hydroxylation of carbon hydrogen bonds of atRA primarily at C-4. Has no activity toward 9-cis and 13-cis retinoic acid stereoisomer [...] (492 aa)    
Predicted Functional Partners:
aldh1a2
Aldehyde dehydrogenase 1 family, member A2; Belongs to the aldehyde dehydrogenase family.
    
 0.997
rdh10b
Retinol dehydrogenase 10-B; Retinol dehydrogenase with a clear preference for NADP. Converts all-trans-retinol to all-trans-retinal. Has no detectable activity towards 11-cis-retinol, 9-cis-retinol and 13-cis-retinol (By similarity); Belongs to the short-chain dehydrogenases/reductases (SDR) family.
   
 
 0.994
dhrs3a
Dehydrogenase/reductase (SDR family) member 3a.
   
 
 0.990
rdh10a
Retinol dehydrogenase 10-A; Retinol dehydrogenase with a clear preference for NADP. Converts all-trans-retinol to all-trans-retinal. Has no detectable activity towards 11-cis-retinol, 9-cis-retinol and 13-cis-retinol (By similarity); Belongs to the short-chain dehydrogenases/reductases (SDR) family.
   
 
 0.985
aldh1a3
Retinaldehyde dehydrogenase family 1 subfamily A3; Belongs to the aldehyde dehydrogenase family.
    
 0.984
sdr16c5b
Short chain dehydrogenase/reductase family 16C, member 5b; Belongs to the short-chain dehydrogenases/reductases (SDR) family.
   
 
 0.971
cyp27c1
Cytochrome P450 27C1; Efficiently catalyzes the conversion of all-trans retinol (also called vitamin A1, the precursor of 11-cis retinal) to 3,4- didehydroretinol (also called vitamin A2, the precursor of 11-cis 3,4- didehydroretinal). Also acts on all-trans retinal and all-trans retinoic acid. The replacement of 11-cis retinal chromophore in photopigments with 11-cis 3,4-didehydroretinal enhances sensitivity to long-wavelength light. This may improve vision in fresh water which is often turbid; Belongs to the cytochrome P450 family.
  
 
0.970
rdh12
Retinol dehydrogenase 12; Belongs to the short-chain dehydrogenases/reductases (SDR) family.
   
 
 0.970
lratb.2
Lecithin retinol acyltransferase b, tandem duplicate 2.
   
 
 0.970
rars1
Arginyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family.
    
 
 0.968
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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