Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
ercc1Excision repair cross-complementing rodent repair deficiency, complementation group 1. (342 aa)    
Predicted Functional Partners:
xpa
Xeroderma pigmentosum, complementation group A.
    
 0.999
mus81
Crossover junction endonuclease MUS81; Interacts with eme1 and eme2 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication forks (By similarity); Belongs to the XPF family.
   
 0.999
ercc4
Excision repair cross-complementation group 4.
   
 0.998
fancm
FA complementation group M.
   
 0.998
ENSDARP00000153311
Helicase ATP-binding domain-containing protein.
   
 0.994
slx1b
Structure-specific endonuclease subunit SLX1; Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA.
   
 0.991
fancd2
FA complementation group D2.
    
 0.987
slx4
SLX4 structure-specific endonuclease subunit homolog (S. cerevisiae).
   
 
 0.982
fancl
FA complementation group L.
    
 0.981
eme1
Essential meiotic structure-specific endonuclease 1.
   
 0.980
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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