Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
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[Homology]
Score
trim35-28Tripartite motif-containing 35-28. (477 aa)    
Predicted Functional Partners:
dnlz
DNL-type zinc finger protein; May function as a co-chaperone towards HSPA9/mortalin which, by itself, is prone to self-aggregation.
   
  
 0.808
ch25hl2
Cholesterol 25-hydroxylase-like protein 2; May catalyze the formation of 25-hydroxycholesterol from cholesterol.
      
 0.720
ch25hl1.1
Cholesterol 25-hydroxylase-like protein 1, member 1; May catalyze the formation of 25-hydroxycholesterol from cholesterol.
      
 0.720
ch25hl1.2
Cholesterol 25-hydroxylase-like protein 1, member 2; May catalyze the formation of 25-hydroxycholesterol from cholesterol.
      
 0.720
ch25hl3
Cholesterol 25-hydroxylase-like 3; Belongs to the sterol desaturase family.
      
 0.662
ftr52p
FinTRIM family, member 52, pseudogene.
    
 
 0.607
ftr06-2
FinTRIM family, member 6.
      
 0.600
wwox
WW domain-containing oxidoreductase; Putative oxidoreductase. Acts as a tumor suppressor and plays a role in apoptosis. May function synergistically with p53/TP53 to control genotoxic stress-induced cell death. Plays a role in TGFB1 signaling and TGFB1-mediated cell death. May also play a role in tumor necrosis factor (TNF)-mediated cell death. Required for normal bone development. Inhibits Wnt signaling (By similarity). Belongs to the short-chain dehydrogenases/reductases (SDR) family.
    
 
 0.534
tnfaip3
Tumor necrosis factor, alpha-induced protein 3.
    
 
 0.501
rnf207b
RING finger protein 207; Plays a role in cardiac repolarization possibly by stabilizing membrane expression of the potassium channel kcnh6a/zerg, or by assisting its synthesis, folding or export from the endoplasmic reticulum, in a heat shock protein-dependent manner.
      
 0.471
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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