STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
irx3bIroquois homeobox 3b. (343 aa)    
Predicted Functional Partners:
hnf1bb
Hepatocyte nuclear factor 1-beta-B; Transcription factor, probably binds to the inverted palindrome 5'-GTTAATNATTAAC-3' (By similarity). Acts downstream of hnf1ba but is not required for induction of rhombomere r5/r6 gene expression in the hindbrain.
    
 
 0.864
hnf1ba
Hepatocyte nuclear factor 1-beta-A; Transcription factor, probably binds to the inverted palindrome 5'-GTTAATNATTAAC-3' (By similarity). Required for induction of rhombomere r5/r6 gene expression in the hindbrain.
    
 
 0.837
pou3f3a
POU domain, class 3, transcription factor 3-A; Transcription factor that may play important roles in patterning the embryonic brain.
   
 
 0.814
sim1a
Single-minded homolog 1-A; Transcriptional factor that may have pleiotropic effects during embryogenesis and in the adult.
      
 0.807
mecom
MDS1 and EVI1 complex locus.
   
 
 0.754
tbx2a
T-box transcription factor 2a.
   
  
 0.750
slc20a1a
Sodium-dependent phosphate transporter 1-A; Sodium-phosphate symporter which plays a fundamental housekeeping role in phosphate transport; Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family.
      
 0.744
zgc:162707
UPF0524 protein C3orf70 homolog B; Plays a role in neuronal and neurobehavioral development. Required for normal expression of the postmitotic and mature neuron markers elavl3 and eno2 and neurobehaviors related to circadian rhythm and altered light-dark conditions.
      
 0.743
C1H3orf70
UPF0524 protein C3orf70 homolog A; Plays a role in neuronal and neurobehavioral development. Required for normal expression of neuronal markers elavl3 and eno2 and neurobehaviors related to circadian rhythm and changes in light-dark conditions.
      
 0.743
slc4a4a
Anion exchange protein.
      
 0.720
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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