Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
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Co-occurrence
Co-expression
Experiments
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[Homology]
Score
sinhcafFamily with sequence similarity 60, member A. (245 aa)    
Predicted Functional Partners:
brms1
BRMS1 transcriptional repressor and anoikis regulator.
    
 0.998
sap130a
Sin3A-associated protein a.
    
 0.997
suds3
Suppressor of defective silencing 3 homolog (SDS3, S. cerevisiae).
    
 0.996
brms1la
Breast cancer metastasis-suppressor 1-like protein-A; Involved in the histone deacetylase (HDAC1)-dependent transcriptional repression activity; Belongs to the BRMS1 family.
    
 0.989
brms1lb
BRMS1-like transcriptional repressor b.
    
 0.989
sin3aa
SIN3 transcription regulator family member Aa.
   
 0.988
sap130b
Sin3A-associated protein b.
    
  0.987
sin3b
SIN3 homolog B, transcription regulator (Yeast).
    
 0.977
sap30l
Histone deacetylase complex subunit SAP30L; Functions as transcription repressor, probably via its interaction with histone deacetylase complexes. Required for normal expression of numerous target genes. Involved in the functional recruitment of the class 1 Sin3-histone deacetylase complex (HDAC) to the nucleolus. Binds DNA, apparently without sequence-specificity, and bends bound double- stranded DNA. Binds phosphoinositol phosphates (phosphoinositol 3- phosphate, phosphoinositol 4-phosphate and phosphoinositol 5-phosphate) via the same basic sequence motif that mediates DNA binding a [...]
    
 
 0.970
phf12a
PHD finger protein 12a.
     
 0.902
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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