fbxw4 protein (Danio rerio) - STRING interaction network

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fbxw4

F-box and WD repeat domain-containing 4. (392 aa)

Predicted Functional Partners:

txndc9

0.967

cct4

0.944

cct5

0.940

skp1

0.938

cct3

0.936

cul1a

0.934

cct7

0.931

cul1b

0.895

PDCL3

0.883

poll

0.872

Your Current Organism:

Danio rerio

NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
PDCL3	cct3	ENSDARP00000135403	ENSDARP00000004738	Phosducin-like protein 3; Acts as a chaperone for the angiogenic VEGF receptor KDR/VEGFR2, increasing its abundance by inhibiting its ubiquitination and degradation. Inhibits the folding activity of the chaperonin-containing T-complex (CCT) which leads to inhibition of cytoskeletal actin folding (By similarity). Acts as a chaperone during heat shock alongside HSP90 and HSP40/70 chaperone complexes (By similarity). Modulates the activation of caspases during apoptosis (By similarity).	T-complex protein 1 subunit gamma.	0.948
PDCL3	cct4	ENSDARP00000135403	ENSDARP00000025466	Phosducin-like protein 3; Acts as a chaperone for the angiogenic VEGF receptor KDR/VEGFR2, increasing its abundance by inhibiting its ubiquitination and degradation. Inhibits the folding activity of the chaperonin-containing T-complex (CCT) which leads to inhibition of cytoskeletal actin folding (By similarity). Acts as a chaperone during heat shock alongside HSP90 and HSP40/70 chaperone complexes (By similarity). Modulates the activation of caspases during apoptosis (By similarity).	T-complex protein 1 subunit delta.	0.933
PDCL3	cct5	ENSDARP00000135403	ENSDARP00000066759	Phosducin-like protein 3; Acts as a chaperone for the angiogenic VEGF receptor KDR/VEGFR2, increasing its abundance by inhibiting its ubiquitination and degradation. Inhibits the folding activity of the chaperonin-containing T-complex (CCT) which leads to inhibition of cytoskeletal actin folding (By similarity). Acts as a chaperone during heat shock alongside HSP90 and HSP40/70 chaperone complexes (By similarity). Modulates the activation of caspases during apoptosis (By similarity).	Chaperonin-containing TCP1, subunit 5 (epsilon).	0.908
PDCL3	cct7	ENSDARP00000135403	ENSDARP00000003107	Phosducin-like protein 3; Acts as a chaperone for the angiogenic VEGF receptor KDR/VEGFR2, increasing its abundance by inhibiting its ubiquitination and degradation. Inhibits the folding activity of the chaperonin-containing T-complex (CCT) which leads to inhibition of cytoskeletal actin folding (By similarity). Acts as a chaperone during heat shock alongside HSP90 and HSP40/70 chaperone complexes (By similarity). Modulates the activation of caspases during apoptosis (By similarity).	T-complex protein 1 subunit eta; Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin.	0.931
PDCL3	fbxw4	ENSDARP00000135403	ENSDARP00000043116	Phosducin-like protein 3; Acts as a chaperone for the angiogenic VEGF receptor KDR/VEGFR2, increasing its abundance by inhibiting its ubiquitination and degradation. Inhibits the folding activity of the chaperonin-containing T-complex (CCT) which leads to inhibition of cytoskeletal actin folding (By similarity). Acts as a chaperone during heat shock alongside HSP90 and HSP40/70 chaperone complexes (By similarity). Modulates the activation of caspases during apoptosis (By similarity).	F-box and WD repeat domain-containing 4.	0.883
PDCL3	txndc9	ENSDARP00000135403	ENSDARP00000121195	Phosducin-like protein 3; Acts as a chaperone for the angiogenic VEGF receptor KDR/VEGFR2, increasing its abundance by inhibiting its ubiquitination and degradation. Inhibits the folding activity of the chaperonin-containing T-complex (CCT) which leads to inhibition of cytoskeletal actin folding (By similarity). Acts as a chaperone during heat shock alongside HSP90 and HSP40/70 chaperone complexes (By similarity). Modulates the activation of caspases during apoptosis (By similarity).	Thioredoxin domain-containing 9.	0.697
cct3	PDCL3	ENSDARP00000004738	ENSDARP00000135403	T-complex protein 1 subunit gamma.	Phosducin-like protein 3; Acts as a chaperone for the angiogenic VEGF receptor KDR/VEGFR2, increasing its abundance by inhibiting its ubiquitination and degradation. Inhibits the folding activity of the chaperonin-containing T-complex (CCT) which leads to inhibition of cytoskeletal actin folding (By similarity). Acts as a chaperone during heat shock alongside HSP90 and HSP40/70 chaperone complexes (By similarity). Modulates the activation of caspases during apoptosis (By similarity).	0.948
cct3	cct4	ENSDARP00000004738	ENSDARP00000025466	T-complex protein 1 subunit gamma.	T-complex protein 1 subunit delta.	0.999
cct3	cct5	ENSDARP00000004738	ENSDARP00000066759	T-complex protein 1 subunit gamma.	Chaperonin-containing TCP1, subunit 5 (epsilon).	0.999
cct3	cct7	ENSDARP00000004738	ENSDARP00000003107	T-complex protein 1 subunit gamma.	T-complex protein 1 subunit eta; Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin.	0.999
cct3	fbxw4	ENSDARP00000004738	ENSDARP00000043116	T-complex protein 1 subunit gamma.	F-box and WD repeat domain-containing 4.	0.936
cct3	txndc9	ENSDARP00000004738	ENSDARP00000121195	T-complex protein 1 subunit gamma.	Thioredoxin domain-containing 9.	0.969
cct4	PDCL3	ENSDARP00000025466	ENSDARP00000135403	T-complex protein 1 subunit delta.	Phosducin-like protein 3; Acts as a chaperone for the angiogenic VEGF receptor KDR/VEGFR2, increasing its abundance by inhibiting its ubiquitination and degradation. Inhibits the folding activity of the chaperonin-containing T-complex (CCT) which leads to inhibition of cytoskeletal actin folding (By similarity). Acts as a chaperone during heat shock alongside HSP90 and HSP40/70 chaperone complexes (By similarity). Modulates the activation of caspases during apoptosis (By similarity).	0.933
cct4	cct3	ENSDARP00000025466	ENSDARP00000004738	T-complex protein 1 subunit delta.	T-complex protein 1 subunit gamma.	0.999
cct4	cct5	ENSDARP00000025466	ENSDARP00000066759	T-complex protein 1 subunit delta.	Chaperonin-containing TCP1, subunit 5 (epsilon).	0.999
cct4	cct7	ENSDARP00000025466	ENSDARP00000003107	T-complex protein 1 subunit delta.	T-complex protein 1 subunit eta; Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin.	0.999
cct4	fbxw4	ENSDARP00000025466	ENSDARP00000043116	T-complex protein 1 subunit delta.	F-box and WD repeat domain-containing 4.	0.944
cct4	txndc9	ENSDARP00000025466	ENSDARP00000121195	T-complex protein 1 subunit delta.	Thioredoxin domain-containing 9.	0.774
cct5	PDCL3	ENSDARP00000066759	ENSDARP00000135403	Chaperonin-containing TCP1, subunit 5 (epsilon).	Phosducin-like protein 3; Acts as a chaperone for the angiogenic VEGF receptor KDR/VEGFR2, increasing its abundance by inhibiting its ubiquitination and degradation. Inhibits the folding activity of the chaperonin-containing T-complex (CCT) which leads to inhibition of cytoskeletal actin folding (By similarity). Acts as a chaperone during heat shock alongside HSP90 and HSP40/70 chaperone complexes (By similarity). Modulates the activation of caspases during apoptosis (By similarity).	0.908
cct5	cct3	ENSDARP00000066759	ENSDARP00000004738	Chaperonin-containing TCP1, subunit 5 (epsilon).	T-complex protein 1 subunit gamma.	0.999

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