STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ciartCircadian associated repressor of transcription (358 aa)    
Predicted Functional Partners:
nr1d1
Nuclear receptor subfamily 1, group d, member 1
   
  
 0.991
cry2
Cryptochrome circadian clock 2; Cryptochrome 3
   
 
 0.990
hsf2
Heat shock factor 2
   
  
 0.987
znf395b
Zinc finger protein 395b
   
    0.987
bhlhe41
Novel protein similar to vertebrate basic helix-loop-helix domain containing, class B, 3 (BHLHB3); Basic helix-loop-helix family, member e41
   
 
 0.978
nr1d2b
Nuclear receptor subfamily 1, group D, member 2b
   
    0.953
cry-dash
Cryptochrome DASH; May have a photoreceptor function (By similarity). Has weak cyclobutyl pyrimidine photolyase activity when expressed in E.coli and when tested in vitro
   
 
 0.753
ddb2
DNA damage-binding protein 2; Required for DNA repair. Binds to ddb1 to form the UV- damaged DNA-binding protein complex (the UV-DDB complex). The UV- DDB complex may recognize UV-induced DNA damage and recruit proteins of the nucleotide excision repair pathway (the NER pathway) to initiate DNA repair. Also appears to function as the substrate recognition module for a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex which may ubiquitinate histone H2A, histone H3 and histone H4 at sites of UV-induced DNA damage. The ubiquitination of histones may facilitate their removal from t [...]
   
  
 0.708
cipca
CLOCK-interacting pacemaker a; Si:dkey-204k5.2
      
 0.706
dbpb
D site of albumin promoter (albumin D-box) binding protein b
   
  
 0.611
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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