Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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experimentally determined
co-expression
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gene neighborhood
gene co-occurrence
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[Homology]
Score
macrod1Mono-ADP ribosylhydrolase 1. (327 aa)    
Predicted Functional Partners:
adprhl2
ADP-ribose glycohydrolase ARH3; ADP-ribose glycohydrolase that preferentially hydrolyzes the scissile alpha-O-linkage attached to the anomeric C1'' position of ADP- ribose and acts on different substrates, such as proteins ADP- ribosylated on serine, free poly(ADP-ribose) and O-acetyl-ADP-D-ribose. Specifically acts as a serine mono-ADP-ribosylhydrolase by mediating the removal of mono-ADP-ribose attached to serine residues on proteins, thereby playing a key role in DNA damage response. Serine ADP- ribosylation of proteins constitutes the primary form of ADP- ribosylation of proteins i [...]
    
 
 0.988
parga
Poly (ADP-ribose) glycohydrolase a.
      
 0.892
parp1
Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair.
    
 
 0.839
naa15a
N(alpha)-acetyltransferase 15, NatA auxiliary subunit a.
    
 
 0.837
flrt1b
Fibronectin leucine-rich transmembrane protein 1b.
      
 0.835
elf2a
E74-like factor 2a (ets domain transcription factor).
      
 0.667
gdap2
Ganglioside-induced differentiation-associated protein 2; Belongs to the GDAP2 family.
  
   
0.657
parp2
Poly [ADP-ribose] polymerase.
    
 
 0.657
akt1s1
AKT1 substrate 1 (proline-rich).
   
    0.633
tep1
Telomerase-associated protein 1.
    
 
 0.632
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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