sde2 protein (Danio rerio) - STRING interaction network

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sde2

Replication stress response regulator SDE2; Involved in both DNA replication and cell cycle control. Unprocessed SDE2 interacts with PCNA via its PIP-box. The interaction with PCNA prevents monoubiquitination of the latter thereby inhibiting translesion DNA synthesis. The binding of SDE2 to PCNA also leads to processing of SDE2 by an unidentified deubiquitinating enzyme, cleaving off the N-terminal ubiquitin-like domain. The resulting mature SDE2 is degraded by the DCX(DTL) complex in a cell cycle- and DNA damage dependent manner. Binding of SDE2 to PCNA is necessary to counteract dama [...] (487 aa)

Predicted Functional Partners:

fam32a

0.999

crnkl1

0.993

prkrip1

0.990

slu7

0.988

cactin

0.987

nkap

0.980

syf2

0.979

cdc40

0.977

ccdc12

0.969

ppil1

0.969

Your Current Organism:

Danio rerio

NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
cactin	ccdc12	ENSDARP00000078145	ENSDARP00000028398	Cactin; May be involved in the regulation of innate immune response (By similarity). Plays a role during early embryonic development. Involved in the formation of the anteroposterior axis with important roles also in neural development; Belongs to the CACTIN family.	Coiled-coil domain-containing 12.	0.925
cactin	cdc40	ENSDARP00000078145	ENSDARP00000060431	Cactin; May be involved in the regulation of innate immune response (By similarity). Plays a role during early embryonic development. Involved in the formation of the anteroposterior axis with important roles also in neural development; Belongs to the CACTIN family.	Cell division cycle 40 homolog (S. cerevisiae).	0.931
cactin	crnkl1	ENSDARP00000078145	ENSDARP00000100660	Cactin; May be involved in the regulation of innate immune response (By similarity). Plays a role during early embryonic development. Involved in the formation of the anteroposterior axis with important roles also in neural development; Belongs to the CACTIN family.	Crooked neck pre-mRNA-splicing factor 1.	0.939
cactin	fam32a	ENSDARP00000078145	ENSDARP00000108572	Cactin; May be involved in the regulation of innate immune response (By similarity). Plays a role during early embryonic development. Involved in the formation of the anteroposterior axis with important roles also in neural development; Belongs to the CACTIN family.	Protein FAM32A-like; May induce G2 arrest and apoptosis. May also increase cell sensitivity to apoptotic stimuli; Belongs to the FAM32 family.	0.989
cactin	nkap	ENSDARP00000078145	ENSDARP00000001288	Cactin; May be involved in the regulation of innate immune response (By similarity). Plays a role during early embryonic development. Involved in the formation of the anteroposterior axis with important roles also in neural development; Belongs to the CACTIN family.	NFKB activating protein-like.	0.947
cactin	ppil1	ENSDARP00000078145	ENSDARP00000127620	Cactin; May be involved in the regulation of innate immune response (By similarity). Plays a role during early embryonic development. Involved in the formation of the anteroposterior axis with important roles also in neural development; Belongs to the CACTIN family.	Peptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family.	0.923
cactin	prkrip1	ENSDARP00000078145	ENSDARP00000045517	Cactin; May be involved in the regulation of innate immune response (By similarity). Plays a role during early embryonic development. Involved in the formation of the anteroposterior axis with important roles also in neural development; Belongs to the CACTIN family.	PRKR-interacting protein 1 homolog; Required for pre-mRNA splicing as component of the spliceosome (By similarity). Binds double-stranded RNA (By similarity).	0.941
cactin	sde2	ENSDARP00000078145	ENSDARP00000043773	Cactin; May be involved in the regulation of innate immune response (By similarity). Plays a role during early embryonic development. Involved in the formation of the anteroposterior axis with important roles also in neural development; Belongs to the CACTIN family.	Replication stress response regulator SDE2; Involved in both DNA replication and cell cycle control. Unprocessed SDE2 interacts with PCNA via its PIP-box. The interaction with PCNA prevents monoubiquitination of the latter thereby inhibiting translesion DNA synthesis. The binding of SDE2 to PCNA also leads to processing of SDE2 by an unidentified deubiquitinating enzyme, cleaving off the N-terminal ubiquitin-like domain. The resulting mature SDE2 is degraded by the DCX(DTL) complex in a cell cycle- and DNA damage dependent manner. Binding of SDE2 to PCNA is necessary to counteract dama [...]	0.987
cactin	slu7	ENSDARP00000078145	ENSDARP00000112935	Cactin; May be involved in the regulation of innate immune response (By similarity). Plays a role during early embryonic development. Involved in the formation of the anteroposterior axis with important roles also in neural development; Belongs to the CACTIN family.	Pre-mRNA-splicing factor SLU7; Required for pre-mRNA splicing as component of the spliceosome. Participates in the second catalytic step of pre-mRNA splicing, when the free hydroxyl group of exon I attacks the 3'-splice site to generate spliced mRNA and the excised lariat intron. Required for holding exon 1 properly in the spliceosome and for correct AG identification when more than one possible AG exists in 3'-splicing site region. May be involved in the activation of proximal AG. Probably also involved in alternative splicing regulation.	0.969
cactin	syf2	ENSDARP00000078145	ENSDARP00000090723	Cactin; May be involved in the regulation of innate immune response (By similarity). Plays a role during early embryonic development. Involved in the formation of the anteroposterior axis with important roles also in neural development; Belongs to the CACTIN family.	Pre-mRNA-splicing factor syf2; Involved in pre-mRNA splicing as component of the spliceosome.	0.937
ccdc12	cactin	ENSDARP00000028398	ENSDARP00000078145	Coiled-coil domain-containing 12.	Cactin; May be involved in the regulation of innate immune response (By similarity). Plays a role during early embryonic development. Involved in the formation of the anteroposterior axis with important roles also in neural development; Belongs to the CACTIN family.	0.925
ccdc12	cdc40	ENSDARP00000028398	ENSDARP00000060431	Coiled-coil domain-containing 12.	Cell division cycle 40 homolog (S. cerevisiae).	0.985
ccdc12	crnkl1	ENSDARP00000028398	ENSDARP00000100660	Coiled-coil domain-containing 12.	Crooked neck pre-mRNA-splicing factor 1.	0.996
ccdc12	fam32a	ENSDARP00000028398	ENSDARP00000108572	Coiled-coil domain-containing 12.	Protein FAM32A-like; May induce G2 arrest and apoptosis. May also increase cell sensitivity to apoptotic stimuli; Belongs to the FAM32 family.	0.940
ccdc12	nkap	ENSDARP00000028398	ENSDARP00000001288	Coiled-coil domain-containing 12.	NFKB activating protein-like.	0.910
ccdc12	ppil1	ENSDARP00000028398	ENSDARP00000127620	Coiled-coil domain-containing 12.	Peptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family.	0.973
ccdc12	prkrip1	ENSDARP00000028398	ENSDARP00000045517	Coiled-coil domain-containing 12.	PRKR-interacting protein 1 homolog; Required for pre-mRNA splicing as component of the spliceosome (By similarity). Binds double-stranded RNA (By similarity).	0.841
ccdc12	sde2	ENSDARP00000028398	ENSDARP00000043773	Coiled-coil domain-containing 12.	Replication stress response regulator SDE2; Involved in both DNA replication and cell cycle control. Unprocessed SDE2 interacts with PCNA via its PIP-box. The interaction with PCNA prevents monoubiquitination of the latter thereby inhibiting translesion DNA synthesis. The binding of SDE2 to PCNA also leads to processing of SDE2 by an unidentified deubiquitinating enzyme, cleaving off the N-terminal ubiquitin-like domain. The resulting mature SDE2 is degraded by the DCX(DTL) complex in a cell cycle- and DNA damage dependent manner. Binding of SDE2 to PCNA is necessary to counteract dama [...]	0.969
ccdc12	slu7	ENSDARP00000028398	ENSDARP00000112935	Coiled-coil domain-containing 12.	Pre-mRNA-splicing factor SLU7; Required for pre-mRNA splicing as component of the spliceosome. Participates in the second catalytic step of pre-mRNA splicing, when the free hydroxyl group of exon I attacks the 3'-splice site to generate spliced mRNA and the excised lariat intron. Required for holding exon 1 properly in the spliceosome and for correct AG identification when more than one possible AG exists in 3'-splicing site region. May be involved in the activation of proximal AG. Probably also involved in alternative splicing regulation.	0.926
ccdc12	syf2	ENSDARP00000028398	ENSDARP00000090723	Coiled-coil domain-containing 12.	Pre-mRNA-splicing factor syf2; Involved in pre-mRNA splicing as component of the spliceosome.	0.994

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