STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
uspl1SUMO-specific isopeptidase USPL1; SUMO-specific isopeptidase involved in protein desumoylation. Specifically binds SUMO proteins with a higher affinity for sumo2 and sumo3 which it cleaves more efficiently. Also able to process full- length SUMO proteins to their mature forms. Plays a key role in RNA polymerase-II-mediated snRNA transcription in the Cajal bodies (By similarity). Is a component of complexes that can bind to U snRNA genes (By similarity). (1014 aa)    
Predicted Functional Partners:
desi1b
PPPDE peptidase domain containing 2b.
      
 0.880
ice2
Interactor of little elongator complex ELL subunit 2.
   
  
 0.868
sumo2a
Small ubiquitin-related modifier.
    
 
 0.862
sumo3b
Small ubiquitin-related modifier.
    
 
 0.861
senp5
SUMO-specific peptidase 5.
   
 
 0.854
desi1a
PPPDE peptidase domain containing 2a.
      
 0.831
snrnp40
Small nuclear ribonucleoprotein 40 (U5).
    
 
 0.812
ell
Elongation factor RNA polymerase II.
   
 
 0.687
snrpa1
Small nuclear ribonucleoprotein polypeptide A.
   
 
 0.684
zc3h4
Zinc finger CCCH-type-containing 4.
    
 
 0.667
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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