| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| cacybp | ctnnb1 | ENSDARP00000089504 | ENSDARP00000139205 | Calcyclin-binding protein. | Catenin beta-1; Key downstream component of the canonical Wnt signaling pathway (By similarity). In the absence of Wnt, forms a complex with axin1, axin2, apc, csnk1a1 and gsk3b that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of ctnnb1 and its subsequent degradation by the proteasome (By similarity). In the presence of Wnt ligand, ctnnb1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes (By similarity). Plays a key role in dorso [...] | 0.902 |
| cacybp | ctnnb2 | ENSDARP00000089504 | ENSDARP00000076115 | Calcyclin-binding protein. | Catenin, beta 2. | 0.902 |
| cacybp | fkbp16 | ENSDARP00000089504 | ENSDARP00000009132 | Calcyclin-binding protein. | Peptidylprolyl isomerase. | 0.600 |
| cacybp | siah1 | ENSDARP00000089504 | ENSDARP00000043842 | Calcyclin-binding protein. | E3 ubiquitin-protein ligase Siah1; E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. It probably triggers the ubiquitin-mediated degradation of different substrates; Belongs to the SINA (Seven in absentia) family. | 0.995 |
| ctnnb1 | cacybp | ENSDARP00000139205 | ENSDARP00000089504 | Catenin beta-1; Key downstream component of the canonical Wnt signaling pathway (By similarity). In the absence of Wnt, forms a complex with axin1, axin2, apc, csnk1a1 and gsk3b that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of ctnnb1 and its subsequent degradation by the proteasome (By similarity). In the presence of Wnt ligand, ctnnb1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes (By similarity). Plays a key role in dorso [...] | Calcyclin-binding protein. | 0.902 |
| ctnnb1 | ctnnb2 | ENSDARP00000139205 | ENSDARP00000076115 | Catenin beta-1; Key downstream component of the canonical Wnt signaling pathway (By similarity). In the absence of Wnt, forms a complex with axin1, axin2, apc, csnk1a1 and gsk3b that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of ctnnb1 and its subsequent degradation by the proteasome (By similarity). In the presence of Wnt ligand, ctnnb1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes (By similarity). Plays a key role in dorso [...] | Catenin, beta 2. | 0.986 |
| ctnnb1 | rps27a | ENSDARP00000139205 | ENSDARP00000128775 | Catenin beta-1; Key downstream component of the canonical Wnt signaling pathway (By similarity). In the absence of Wnt, forms a complex with axin1, axin2, apc, csnk1a1 and gsk3b that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of ctnnb1 and its subsequent degradation by the proteasome (By similarity). In the presence of Wnt ligand, ctnnb1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes (By similarity). Plays a key role in dorso [...] | Ribosomal protein S27a. | 0.670 |
| ctnnb1 | siah1 | ENSDARP00000139205 | ENSDARP00000043842 | Catenin beta-1; Key downstream component of the canonical Wnt signaling pathway (By similarity). In the absence of Wnt, forms a complex with axin1, axin2, apc, csnk1a1 and gsk3b that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of ctnnb1 and its subsequent degradation by the proteasome (By similarity). In the presence of Wnt ligand, ctnnb1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes (By similarity). Plays a key role in dorso [...] | E3 ubiquitin-protein ligase Siah1; E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. It probably triggers the ubiquitin-mediated degradation of different substrates; Belongs to the SINA (Seven in absentia) family. | 0.987 |
| ctnnb2 | cacybp | ENSDARP00000076115 | ENSDARP00000089504 | Catenin, beta 2. | Calcyclin-binding protein. | 0.902 |
| ctnnb2 | ctnnb1 | ENSDARP00000076115 | ENSDARP00000139205 | Catenin, beta 2. | Catenin beta-1; Key downstream component of the canonical Wnt signaling pathway (By similarity). In the absence of Wnt, forms a complex with axin1, axin2, apc, csnk1a1 and gsk3b that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of ctnnb1 and its subsequent degradation by the proteasome (By similarity). In the presence of Wnt ligand, ctnnb1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes (By similarity). Plays a key role in dorso [...] | 0.986 |
| ctnnb2 | siah1 | ENSDARP00000076115 | ENSDARP00000043842 | Catenin, beta 2. | E3 ubiquitin-protein ligase Siah1; E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. It probably triggers the ubiquitin-mediated degradation of different substrates; Belongs to the SINA (Seven in absentia) family. | 0.955 |
| fkbp16 | cacybp | ENSDARP00000009132 | ENSDARP00000089504 | Peptidylprolyl isomerase. | Calcyclin-binding protein. | 0.600 |
| fkbp16 | pink1 | ENSDARP00000009132 | ENSDARP00000014981 | Peptidylprolyl isomerase. | PTEN-induced kinase 1. | 0.592 |
| fkbp16 | rhot1b | ENSDARP00000009132 | ENSDARP00000140377 | Peptidylprolyl isomerase. | Mitochondrial Rho GTPase; Mitochondrial GTPase involved in mitochondrial trafficking. Belongs to the mitochondrial Rho GTPase family. | 0.957 |
| fkbp16 | rhot2 | ENSDARP00000009132 | ENSDARP00000061202 | Peptidylprolyl isomerase. | Mitochondrial Rho GTPase 2; Mitochondrial GTPase involved in mitochondrial trafficking. Probably involved in control of anterograde transport of mitochondria and their subcellular distribution (By similarity). | 0.934 |
| fkbp16 | rps27a | ENSDARP00000009132 | ENSDARP00000128775 | Peptidylprolyl isomerase. | Ribosomal protein S27a. | 0.936 |
| fkbp16 | siah1 | ENSDARP00000009132 | ENSDARP00000043842 | Peptidylprolyl isomerase. | E3 ubiquitin-protein ligase Siah1; E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. It probably triggers the ubiquitin-mediated degradation of different substrates; Belongs to the SINA (Seven in absentia) family. | 0.951 |
| fkbp16 | tomm70a | ENSDARP00000009132 | ENSDARP00000117083 | Peptidylprolyl isomerase. | Translocase of outer mitochondrial membrane 70 homolog A (S. cerevisiae). | 0.892 |
| pink1 | fkbp16 | ENSDARP00000014981 | ENSDARP00000009132 | PTEN-induced kinase 1. | Peptidylprolyl isomerase. | 0.592 |
| pink1 | rhot1b | ENSDARP00000014981 | ENSDARP00000140377 | PTEN-induced kinase 1. | Mitochondrial Rho GTPase; Mitochondrial GTPase involved in mitochondrial trafficking. Belongs to the mitochondrial Rho GTPase family. | 0.798 |
