Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
zgc:161973Zgc:161973 protein. (487 aa)    
Predicted Functional Partners:
skp1
S-phase kinase-associated protein 1A; Belongs to the SKP1 family.
    
 0.867
micos10
MICOS complex subunit MIC10; Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.
      
 0.602
rbx1
Ring-box 1, E3 ubiquitin protein ligase.
    
 0.533
cul1a
Cullin 1a; Belongs to the cullin family.
    
 0.532
cand1
Cullin-associated and neddylation-dissociated 1.
   
 
  0.519
fbxl5
F-box/LRR-repeat protein 5; Component of some SCF (SKP1-cullin-F-box) protein ligase complex that plays a central role in iron homeostasis by promoting the ubiquitination and subsequent degradation of ireb2/irp2. Upon high iron and oxygen level, it specifically recognizes and binds ireb2/irp2, promoting its ubiquitination and degradation by the proteasome (By similarity).
     
 0.518
commd5
COMM domain-containing 5.
     
 0.513
commd2
COMM domain-containing 2.
     
  0.500
commd7
COMM domain-containing 7.
     
  0.500
commd3
COMM domain-containing 3.
     
  0.500
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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