Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
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Experiments
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[Homology]
Score
ank2bAnkyrin 2b, neuronal. (312 aa)    
Predicted Functional Partners:
ank3b-2
Zgc:171763 protein.
 
   
 0.949
ank2a
Ankyrin 2a, neuronal.
     
  0.813
chd8
Chromodomain-helicase-DNA-binding protein 8; DNA helicase that acts as a chromatin remodeling factor and regulates transcription. Acts as a transcription repressor by remodeling chromatin structure and recruiting histone H1 to target genes. Suppresses p53/tp53-mediated apoptosis by recruiting histone H1 and preventing p53/tp53 transactivation activity. Acts as a negative regulator of Wnt signaling pathway by regulating beta-catenin (ctnnb1) activity. Negatively regulates ctnnb1-targeted gene expression by being recruited specifically to the promoter regions of several ctnnb1 responsive [...]
    
 
 0.597
A2BIM2_DANRE
Si:ch211-203b8.6.
 
 
 
0.591
ank1a
Ankyrin 1, erythrocytic a.
 
 
 
 0.529
A5WV38_DANRE
Si:ch211-209a2.2.
  
 
  0.528
nfkbib
Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta.
  
 
  0.524
ankdd1b
Ankyrin repeat and death domain-containing 1B.
  
  
0.506
zmat3
Zinc finger, matrin-type 3.
      
 0.489
ankrd45
Ankyrin repeat domain 45.
    
 
 0.485
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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