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her12 protein (Danio rerio) - STRING interaction network
"her12" - BHLH transcription factor in Danio rerio
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
her12BHLH transcription factor; Hairy-related 12 (155 aa)    
Predicted Functional Partners:
ENSDARG00000077129
Notch homolog 1a (378 aa)
           
  0.703
notch1a
Neurogenic locus notch homolog protein 1; Functions as a receptor for membrane-bound ligands jagged1, jagged2 and delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting. Involved in the maturation of both CD4+ [...] (1655 aa)
           
  0.702
neurog1
Neurogenin-1; Transcriptional regulator. Activates transcription by binding to the E box-containing promoter (By similarity). Mediates neuronal differentiation. Required for the development of Rohon- Beard spinal sensory neurons and dorsal root ganglion neurons, but not for primary motoneurons or autonomic neurons. Required for development of all cranial ganglia but not associated glial cells. Regulates epiphysial neurogenesis, acting partially redundantly with ascl1a and downstream of flh. Required for the development of basal forebrain dopaminergic neurons; involved in the specificat [...] (208 aa)
     
   
  0.687
hand2
Heart- and neural crest derivatives-expressed protein 2; Essential for myocardial and pectoral fin differentiation, patterning and morphogenesis (205 aa)
           
  0.684
atoh7
Protein atonal homolog 7; Transcription factor involved in the differentiation of retinal ganglion cells (134 aa)
           
  0.683
neurod
Neurogenic differentiation factor 1; May act as a transcriptional activator. Differentiation factor required for neurogenesis. Acts as an upstream activator of isl1 (350 aa)
           
  0.683
neurog3
Neurog3 protein; Neurogenin 3 (208 aa)
           
  0.682
her1
Hairy-related 1 (328 aa)
           
  0.681
olig2
Oligodendrocyte lineage transcription factor 2 (273 aa)
     
   
  0.607
atoh1a
Atonal bHLH transcription factor 1a; Atonal homolog 1a (292 aa)
           
  0.600
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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