Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
hpnNovel protein similar to H.sapiens HPN, hepsin (Transmembrane protease, serine 1) (HPN); Belongs to the peptidase S1 family. (425 aa)    
Predicted Functional Partners:
F8W2U8_DANRE
Si:dkeyp-52c3.7.
      
 0.737
kcnk18
Potassium channel, subfamily K, member 18; Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
      
 0.662
pdzd3a
PDZ domain-containing 3a.
      
 0.660
magi3a
Wu:fi36a10.
   
 
 0.647
gramd1a
GRAM domain-containing 1A.
 
    
 0.621
plgrkt
Plasminogen receptor, C-terminal lysine transmembrane protein.
    
 
 0.617
E7FGQ0_DANRE
Si:ch73-206d17.1.
     
 0.598
asah2
Neutral ceramidase; Plasma membrane ceramidase that hydrolyzes sphingolipid ceramides into sphingosine and free fatty acids at neutral pH. Ceramides, sphingosine, and its phosphorylated form sphingosine-1-phosphate are bioactive lipids that mediate cellular signaling pathways regulating several biological processes including cell proliferation, apoptosis and differentiation. Also catalyzes the reverse reaction allowing the synthesis of ceramides from fatty acids and sphingosine. Together with sphingomyelinase, participates in the production of sphingosine and sphingosine-1-phosphate fr [...]
      
 0.582
zbtb16b
Zinc finger and BTB domain-containing 16b.
    
 
 0.580
agrn
Agrin.
   
 
 0.565
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
Server load: low (24%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.