Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
INSM2INSM transcriptional repressor 2. (449 aa)    
Predicted Functional Partners:
fam177a1
Family with sequence similarity 177 member A1.
      
 0.785
fam49a
Family with sequence similarity 49 member A.
      
 0.772
gpn1
GPN-loop GTPase; Small GTPase required for proper nuclear import of RNA polymerase II (RNAPII). May act at an RNAP assembly step prior to nuclear import.
      
 0.756
ralgapa1
Ral GTPase-activating protein, alpha subunit 1 (catalytic).
      
 0.740
eed
Polycomb protein eed; Polycomb group (PcG) protein. Component of the prc2/eed-ezh2 complex, which methylates 'Lys-9' and 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene (By similarity).
      
 0.690
eapp
E2f-associated phosphoprotein.
      
 0.688
fxyd6
FXYD domain-containing ion transport regulator; Belongs to the FXYD family.
      
 0.670
sptssa
Serine palmitoyltransferase small subunit A; Stimulates the activity of serine palmitoyltransferase (SPT). The composition of the serine palmitoyltransferase (SPT) complex determines the substrate preference (By similarity). Belongs to the SPTSS family. SPTSSA subfamily.
      
 0.661
neurog3
Neurog3 protein.
   
 
 0.650
tead3b
TEA domain family member 3 b.
    
 
 0.643
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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