Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
hif1aaHypoxia-inducible factor 1 subunit alpha a. (717 aa)    
Predicted Functional Partners:
arnt
Aryl hydrocarbon receptor nuclear translocator.
   
0.958
cul2
Cullin 2; Belongs to the cullin family.
    
 0.950
vhl
Von Hippel-Lindau tumor suppressor.
    
 0.944
hif1al
Hypoxia-inducible factor 1 subunit alpha,-like.
  
  
0.925
hif1ab
Hypoxia-inducible factor 1 subunit alpha b.
  
  
0.897
eloca
Elongin C paralog a; Belongs to the SKP1 family.
    
 0.896
arnt2
Aryl hydrocarbon receptor nuclear translocator 2; Transcription factor that plays a role in the development of the hypothalamo-pituitary axis. Specifically recognizes the xenobiotic response element (XRE) (By similarity). Isoform 1 acts as a transcriptional activator. Isoform 3 acts as a transcriptional repressor.
   
 0.893
tp53
Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of bax and fas antigen expression, or by repression of Bcl-2 expression.
    
 
 0.876
egln2
Egl-9 family hypoxia-inducible factor 2.
   
 0.876
egln3
Egl-9 family hypoxia-inducible factor 3.
    
 0.875
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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