STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
mysm1Histone H2A deubiquitinase MYSM1; Metalloprotease that specifically deubiquitinates monoubiquitinated histone H2A, a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Preferentially deubiquitinates monoubiquitinated H2A in hyperacetylated nucleosomes. Deubiquitination of histone H2A leads to facilitate the phosphorylation and dissociation of histone H1 from the nucleosome. Acts as a coactivator by participating in the initiation and elongation steps of androgen receptor (AR)-induced gene activation (By similarity). (822 aa)    
Predicted Functional Partners:
kat2b
Histone acetyltransferase KAT2B; Functions as a histone acetyltransferase (HAT) to promote transcriptional activation (By similarity). Has significant histone acetyltransferase activity with core histones (H3 and H4), and also with nucleosome core particles (By similarity). Also acetylates non- histone proteins. Involved in heart and limb development by mediating acetylation of tbx5. Also acetylates spermidine (By similarity). Together with kat2a, required for growth and differentiation of craniofacial cartilage and bone by regulating acetylation of histone H3 at 'Lys-9' (H3K9ac) ; Bel [...]
   
 0.960
psmd7
Proteasome (Prosome, macropain) 26S subunit, non-ATPase, 7 (Mov34 homolog).
   
 
 0.959
psmd6
Proteasome 26S subunit, non-ATPase 6.
   
 
 0.946
psmc3
Proteasome 26S subunit, ATPase 3; Belongs to the AAA ATPase family.
  
 
 0.938
psmd13
Proteasome (Prosome, macropain) 26S subunit, non-ATPase, 13.
   
 
 0.936
psmb2
Proteasome subunit beta.
   
 
 0.933
psmd12
Proteasome (Prosome, macropain) 26S subunit, non-ATPase, 12.
   
 
 0.932
psma1
Proteasome subunit alpha type.
   
 
 0.932
psmd3
Proteasome (Prosome, macropain) 26S subunit, non-ATPase, 3.
   
 
 0.931
psma3
Proteasome subunit alpha type.
   
 
 0.930
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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