node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
kat2b | mysm1 | ENSDARP00000085190 | ENSDARP00000107103 | Histone acetyltransferase KAT2B; Functions as a histone acetyltransferase (HAT) to promote transcriptional activation (By similarity). Has significant histone acetyltransferase activity with core histones (H3 and H4), and also with nucleosome core particles (By similarity). Also acetylates non- histone proteins. Involved in heart and limb development by mediating acetylation of tbx5. Also acetylates spermidine (By similarity). Together with kat2a, required for growth and differentiation of craniofacial cartilage and bone by regulating acetylation of histone H3 at 'Lys-9' (H3K9ac) ; Bel [...] | Histone H2A deubiquitinase MYSM1; Metalloprotease that specifically deubiquitinates monoubiquitinated histone H2A, a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Preferentially deubiquitinates monoubiquitinated H2A in hyperacetylated nucleosomes. Deubiquitination of histone H2A leads to facilitate the phosphorylation and dissociation of histone H1 from the nucleosome. Acts as a coactivator by participating in the initiation and elongation steps of androgen receptor (AR)-induced gene activation (By similarity). | 0.960 |
mysm1 | kat2b | ENSDARP00000107103 | ENSDARP00000085190 | Histone H2A deubiquitinase MYSM1; Metalloprotease that specifically deubiquitinates monoubiquitinated histone H2A, a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Preferentially deubiquitinates monoubiquitinated H2A in hyperacetylated nucleosomes. Deubiquitination of histone H2A leads to facilitate the phosphorylation and dissociation of histone H1 from the nucleosome. Acts as a coactivator by participating in the initiation and elongation steps of androgen receptor (AR)-induced gene activation (By similarity). | Histone acetyltransferase KAT2B; Functions as a histone acetyltransferase (HAT) to promote transcriptional activation (By similarity). Has significant histone acetyltransferase activity with core histones (H3 and H4), and also with nucleosome core particles (By similarity). Also acetylates non- histone proteins. Involved in heart and limb development by mediating acetylation of tbx5. Also acetylates spermidine (By similarity). Together with kat2a, required for growth and differentiation of craniofacial cartilage and bone by regulating acetylation of histone H3 at 'Lys-9' (H3K9ac) ; Bel [...] | 0.960 |
mysm1 | psma1 | ENSDARP00000107103 | ENSDARP00000134179 | Histone H2A deubiquitinase MYSM1; Metalloprotease that specifically deubiquitinates monoubiquitinated histone H2A, a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Preferentially deubiquitinates monoubiquitinated H2A in hyperacetylated nucleosomes. Deubiquitination of histone H2A leads to facilitate the phosphorylation and dissociation of histone H1 from the nucleosome. Acts as a coactivator by participating in the initiation and elongation steps of androgen receptor (AR)-induced gene activation (By similarity). | Proteasome subunit alpha type. | 0.932 |
mysm1 | psma3 | ENSDARP00000107103 | ENSDARP00000108560 | Histone H2A deubiquitinase MYSM1; Metalloprotease that specifically deubiquitinates monoubiquitinated histone H2A, a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Preferentially deubiquitinates monoubiquitinated H2A in hyperacetylated nucleosomes. Deubiquitination of histone H2A leads to facilitate the phosphorylation and dissociation of histone H1 from the nucleosome. Acts as a coactivator by participating in the initiation and elongation steps of androgen receptor (AR)-induced gene activation (By similarity). | Proteasome subunit alpha type. | 0.930 |
mysm1 | psmb2 | ENSDARP00000107103 | ENSDARP00000041113 | Histone H2A deubiquitinase MYSM1; Metalloprotease that specifically deubiquitinates monoubiquitinated histone H2A, a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Preferentially deubiquitinates monoubiquitinated H2A in hyperacetylated nucleosomes. Deubiquitination of histone H2A leads to facilitate the phosphorylation and dissociation of histone H1 from the nucleosome. Acts as a coactivator by participating in the initiation and elongation steps of androgen receptor (AR)-induced gene activation (By similarity). | Proteasome subunit beta. | 0.933 |
mysm1 | psmc3 | ENSDARP00000107103 | ENSDARP00000026554 | Histone H2A deubiquitinase MYSM1; Metalloprotease that specifically deubiquitinates monoubiquitinated histone H2A, a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Preferentially deubiquitinates monoubiquitinated H2A in hyperacetylated nucleosomes. Deubiquitination of histone H2A leads to facilitate the phosphorylation and dissociation of histone H1 from the nucleosome. Acts as a coactivator by participating in the initiation and elongation steps of androgen receptor (AR)-induced gene activation (By similarity). | Proteasome 26S subunit, ATPase 3; Belongs to the AAA ATPase family. | 0.938 |
mysm1 | psmd12 | ENSDARP00000107103 | ENSDARP00000106592 | Histone H2A deubiquitinase MYSM1; Metalloprotease that specifically deubiquitinates monoubiquitinated histone H2A, a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Preferentially deubiquitinates monoubiquitinated H2A in hyperacetylated nucleosomes. Deubiquitination of histone H2A leads to facilitate the phosphorylation and dissociation of histone H1 from the nucleosome. Acts as a coactivator by participating in the initiation and elongation steps of androgen receptor (AR)-induced gene activation (By similarity). | Proteasome (Prosome, macropain) 26S subunit, non-ATPase, 12. | 0.932 |
mysm1 | psmd13 | ENSDARP00000107103 | ENSDARP00000095348 | Histone H2A deubiquitinase MYSM1; Metalloprotease that specifically deubiquitinates monoubiquitinated histone H2A, a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Preferentially deubiquitinates monoubiquitinated H2A in hyperacetylated nucleosomes. Deubiquitination of histone H2A leads to facilitate the phosphorylation and dissociation of histone H1 from the nucleosome. Acts as a coactivator by participating in the initiation and elongation steps of androgen receptor (AR)-induced gene activation (By similarity). | Proteasome (Prosome, macropain) 26S subunit, non-ATPase, 13. | 0.936 |
mysm1 | psmd3 | ENSDARP00000107103 | ENSDARP00000025779 | Histone H2A deubiquitinase MYSM1; Metalloprotease that specifically deubiquitinates monoubiquitinated histone H2A, a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Preferentially deubiquitinates monoubiquitinated H2A in hyperacetylated nucleosomes. Deubiquitination of histone H2A leads to facilitate the phosphorylation and dissociation of histone H1 from the nucleosome. Acts as a coactivator by participating in the initiation and elongation steps of androgen receptor (AR)-induced gene activation (By similarity). | Proteasome (Prosome, macropain) 26S subunit, non-ATPase, 3. | 0.931 |
mysm1 | psmd6 | ENSDARP00000107103 | ENSDARP00000094762 | Histone H2A deubiquitinase MYSM1; Metalloprotease that specifically deubiquitinates monoubiquitinated histone H2A, a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Preferentially deubiquitinates monoubiquitinated H2A in hyperacetylated nucleosomes. Deubiquitination of histone H2A leads to facilitate the phosphorylation and dissociation of histone H1 from the nucleosome. Acts as a coactivator by participating in the initiation and elongation steps of androgen receptor (AR)-induced gene activation (By similarity). | Proteasome 26S subunit, non-ATPase 6. | 0.946 |
mysm1 | psmd7 | ENSDARP00000107103 | ENSDARP00000134068 | Histone H2A deubiquitinase MYSM1; Metalloprotease that specifically deubiquitinates monoubiquitinated histone H2A, a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Preferentially deubiquitinates monoubiquitinated H2A in hyperacetylated nucleosomes. Deubiquitination of histone H2A leads to facilitate the phosphorylation and dissociation of histone H1 from the nucleosome. Acts as a coactivator by participating in the initiation and elongation steps of androgen receptor (AR)-induced gene activation (By similarity). | Proteasome (Prosome, macropain) 26S subunit, non-ATPase, 7 (Mov34 homolog). | 0.959 |
psma1 | mysm1 | ENSDARP00000134179 | ENSDARP00000107103 | Proteasome subunit alpha type. | Histone H2A deubiquitinase MYSM1; Metalloprotease that specifically deubiquitinates monoubiquitinated histone H2A, a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Preferentially deubiquitinates monoubiquitinated H2A in hyperacetylated nucleosomes. Deubiquitination of histone H2A leads to facilitate the phosphorylation and dissociation of histone H1 from the nucleosome. Acts as a coactivator by participating in the initiation and elongation steps of androgen receptor (AR)-induced gene activation (By similarity). | 0.932 |
psma1 | psma3 | ENSDARP00000134179 | ENSDARP00000108560 | Proteasome subunit alpha type. | Proteasome subunit alpha type. | 0.999 |
psma1 | psmb2 | ENSDARP00000134179 | ENSDARP00000041113 | Proteasome subunit alpha type. | Proteasome subunit beta. | 0.999 |
psma1 | psmc3 | ENSDARP00000134179 | ENSDARP00000026554 | Proteasome subunit alpha type. | Proteasome 26S subunit, ATPase 3; Belongs to the AAA ATPase family. | 0.999 |
psma1 | psmd12 | ENSDARP00000134179 | ENSDARP00000106592 | Proteasome subunit alpha type. | Proteasome (Prosome, macropain) 26S subunit, non-ATPase, 12. | 0.998 |
psma1 | psmd13 | ENSDARP00000134179 | ENSDARP00000095348 | Proteasome subunit alpha type. | Proteasome (Prosome, macropain) 26S subunit, non-ATPase, 13. | 0.996 |
psma1 | psmd3 | ENSDARP00000134179 | ENSDARP00000025779 | Proteasome subunit alpha type. | Proteasome (Prosome, macropain) 26S subunit, non-ATPase, 3. | 0.992 |
psma1 | psmd6 | ENSDARP00000134179 | ENSDARP00000094762 | Proteasome subunit alpha type. | Proteasome 26S subunit, non-ATPase 6. | 0.998 |
psma1 | psmd7 | ENSDARP00000134179 | ENSDARP00000134068 | Proteasome subunit alpha type. | Proteasome (Prosome, macropain) 26S subunit, non-ATPase, 7 (Mov34 homolog). | 0.998 |