Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
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Co-occurrence
Co-expression
Experiments
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[Homology]
Score
ric8aSynembryn-A; Guanine nucleotide exchange factor (GEF), which can activate some, but not all, G-alpha proteins by exchanging bound GDP for free GTP. Involved in regulation of microtubule pulling forces during mitotic movement of chromosomes by stimulating G(i)-alpha protein (By similarity). (550 aa)    
Predicted Functional Partners:
ncs1a
Neuronal calcium sensor 1a.
    
 
 0.910
ncs1b
Frequenin homolog b (Drosophila).
    
 
 0.844
dctn2
Dynactin subunit 2; Modulates cytoplasmic dynein binding to an organelle, and plays a role in prometaphase chromosome alignment and spindle organization during mitosis. Involved in anchoring microtubules to centrosomes. May play a role in synapse formation during brain development (By similarity).
    
 
 0.745
rabif
RAB-interacting factor.
      
 0.723
gnaq
Guanine nucleotide-binding protein (G protein), q polypeptide.
    
 
 0.687
gnas
GNAS complex locus.
   
 
 0.659
gna11a
Guanine nucleotide-binding protein (G protein), alpha 11a (Gq class).
    
 
 0.657
wfs1a
Wolfram syndrome 1a (wolframin).
   
    0.648
wfs1b
Wolfram syndrome 1b (wolframin).
   
    0.648
ntsr1
Neurotensin receptor 1 (high affinity); Belongs to the G-protein coupled receptor 1 family.
      
 0.634
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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