Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
ndrg1aN-myc downstream regulated gene 1 protein, ndrg1. (392 aa)    
Predicted Functional Partners:
mycn
N-myc protein; May function as a transcription factor.
    
 
 0.686
atp1a1a.4
Sodium/potassium-transporting ATPase subunit alpha.
   
 
 0.615
sgk1
Serine/threonine-protein kinase Sgk1; Protein kinase that may play an important role in cellular stress response. May be involved in the regulation of processes such as cell survival, neuronal excitability and renal sodium excretion (By similarity); Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.
    
 
 0.598
sh3tc2
SH3 domain and tetratricopeptide repeats 2.
      
 0.549
nmrk1
Nicotinamide riboside kinase 1.
    
 
 0.546
atp1a1a.5
Sodium/potassium-transporting ATPase subunit alpha.
   
 
 0.537
sgk3
Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.
    
 
 0.520
atp1a1a.2
Sodium/potassium-transporting ATPase subunit alpha.
   
 
 0.514
ppp4r2a
Serine/threonine-protein phosphatase 4 regulatory subunit 2-A; Regulatory subunit of serine/threonine-protein phosphatase 4 (PP4C); Belongs to the PPP4R2 family.
      
 0.487
eif3ea
Eukaryotic translation initiation factor 3 subunit E-A; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.
    
 
 0.487
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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