Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
camk2d2Calcium/calmodulin-dependent protein kinase type II delta 2 chain; CaM-kinase II (CAMK2) is a prominent kinase in the central nervous system. (554 aa)    
Predicted Functional Partners:
ryr2b
Ryanodine receptor 2b (cardiac).
    
 0.915
RYR2
Uncharacterized protein.
    
 0.913
calml4a
Calmodulin-like 4a.
    
 0.882
plcg1
Phosphoinositide phospholipase C.
    
 0.874
camk2a
Calcium/calmodulin-dependent protein kinase II alpha; Belongs to the protein kinase superfamily.
  
 
0.862
cybb
Cytochrome b-245, beta polypeptide (chronic granulomatous disease).
     
  0.856
PLCB4
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.
   
 0.856
calm2a
Calmodulin; Calmodulin mediates the control of a large number of enzymes, ion channels and other proteins by Ca(2+). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases.
   
 0.848
plcb3
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.
   
 0.848
calm3a
Calmodulin 3a (phosphorylase kinase, delta).
   
 0.848
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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