Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
cdk10Cyclin-dependent kinase 10; Belongs to the protein kinase superfamily. (360 aa)    
Predicted Functional Partners:
ccnq
Cyclin-Q; May be an activating cyclin for the cyclin-associated kinase CDK10.
   
 
 0.854
ccnl1a
Novel protein similar to vertebrate cyclin L1 (CCNL1); Belongs to the cyclin family.
   
 
 0.816
sap30bp
SAP30-binding protein.
   
   0.769
ets2
V-ets avian erythroblastosis virus E26 oncogene homolog 2.
    
 
 0.742
ccnl1b
Cyclin-L1; Involved in pre-mRNA splicing.
   
 
 0.701
ccng2
Cyclin G2; Belongs to the cyclin family.
      
 0.646
mea1
Male-enhanced antigen 1.
      
 0.633
def8
Differentially-expressed in FDCP 8 homolog.
      
 0.566
ccnk
Cyclin-K; Regulatory subunit of cyclin-dependent kinases that mediates activation of target kinases. Plays a role in transcriptional regulation via its role in regulating the phosphorylation of the C- terminal domain (CTD) of the large subunit of RNA polymerase II (POLR2A).
   
 
 0.551
det1
DET1 partner of COP1 E3 ubiquitin ligase.
      
 0.503
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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