Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
aco1Aconitase 1, soluble; Belongs to the aconitase/IPM isomerase family. (890 aa)    
Predicted Functional Partners:
cs
Citrate synthase, mitochondrial.
  
 0.996
idh1
Isocitrate dehydrogenase [NADP]; Belongs to the isocitrate and isopropylmalate dehydrogenases family.
  
 0.990
idh3a
Isocitrate dehydrogenase [NAD] subunit, mitochondrial.
  
 0.978
idh3g
Isocitrate dehydrogenase [NAD] subunit, mitochondrial.
  
 0.977
idh2
Isocitrate dehydrogenase (NADP(+)) 2.
  
 0.972
idh3b
Isocitrate dehydrogenase [NAD] subunit, mitochondrial.
  
 0.970
fbxl5
F-box/LRR-repeat protein 5; Component of some SCF (SKP1-cullin-F-box) protein ligase complex that plays a central role in iron homeostasis by promoting the ubiquitination and subsequent degradation of ireb2/irp2. Upon high iron and oxygen level, it specifically recognizes and binds ireb2/irp2, promoting its ubiquitination and degradation by the proteasome (By similarity).
    
 
 0.958
aco2
Aconitate hydratase, mitochondrial; Belongs to the aconitase/IPM isomerase family.
   
 
 0.952
aclyb
ATP-citrate synthase; In the C-terminal section; belongs to the succinate/malate CoA ligase alpha subunit family.
  
 0.941
aclya
ATP-citrate synthase; In the C-terminal section; belongs to the succinate/malate CoA ligase alpha subunit family.
  
 0.925
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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