Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
spred2bSprouty-related, EVH1 domain-containing protein 2; Negatively regulates Ras signaling pathways and downstream activation of MAP kinases. (413 aa)    
Predicted Functional Partners:
nf1b
Neurofibromin 1b.
    
 0.873
spred1
Sprouty-related EVH1 domain-containing 1.
  
 
0.819
fgfrl1a
Fibroblast growth factor receptor-like 1a.
     
 0.714
nras
GTPase NRas; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity; Belongs to the small GTPase superfamily. Ras family.
   
 0.706
kras
V-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog.
   
 0.702
rasa1a
RAS p21 protein activator (GTPase-activating protein) 1a.
     
 0.689
hrasb
-Ha-ras Harvey rat sarcoma viral oncogene homolog, like.
   
  0.648
nf1a
Neurofibromin 1a.
    
 
 0.632
ofd1
Oral-facial-digital syndrome 1 protein homolog; Component of the centrioles controlling mother and daughter centrioles length. Involved in the biogenesis of the cilium, a centriole-associated function. The cilium is a cell surface projection found in many vertebrate cells required to transduce signals important for development and tissue homeostasis. Plays an important role in development by regulating Wnt signaling and the specification of the left-right axis; Belongs to the OFD1 family.
    
 
 0.600
psma2
Proteasome subunit alpha type.
     
 0.577
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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