STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
spred2bSprouty-related, EVH1 domain-containing protein 2; Negatively regulates Ras signaling pathways and downstream activation of MAP kinases. (413 aa)    
Predicted Functional Partners:
nf1a
Neurofibromin 1a.
   
 
 0.722
nf1b
Neurofibromin 1b.
    
 
 0.618
etaa1
ETAA1 activator of ATR kinase.
      
 0.600
spry1
Sprouty homolog 1, antagonist of FGF-signaling (Drosophila).
  
   
 0.558
tnip2
TNFAIP3-interacting protein 2.
      
 0.555
rasa1a
RAS p21 protein activator (GTPase-activating protein) 1a.
      
 0.504
nbr1a
NBR1 autophagy cargo receptor a.
    
 
 0.496
ttc7b
Tetratricopeptide repeat domain 7B.
   
  
 0.486
spry4
Sprouty homolog 4 (Drosophila).
   
  
 0.474
spry2
Sprouty RTK-signaling antagonist 2.
  
  
 0.455
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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