Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
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[Homology]
Score
syt4Synaptotagmin IV. (439 aa)    
Predicted Functional Partners:
stx1b
Syntaxin 1B; Belongs to the syntaxin family.
   
 
 0.739
syt1a
Synaptotagmin Ia.
  
 
0.681
cdk5r2a
Cyclin-dependent kinase 5 activator.
   
  
 0.652
snap25b
Synaptosomal-associated protein 25-B; May play an important role in the synaptic function of specific neuronal systems. Associates with proteins involved in vesicle docking and membrane fusion; Belongs to the SNAP-25 family.
   
 
 0.646
snap25a
Synaptosomal-associated protein 25-A; May play an important role in the synaptic function of specific neuronal systems. Associates with proteins involved in vesicle docking and membrane fusion; Belongs to the SNAP-25 family.
   
 
 0.640
syn1
Synapsin I.
    
 
 0.631
pcsk2
Proprotein convertase subtilisin/kexin type 2; Belongs to the peptidase S8 family.
   
  
 0.595
adam23a
ADAM metallopeptidase domain 23a.
   
  
 0.583
ptprna
Protein tyrosine phosphatase receptor type Na.
   
  
 0.577
syn2a
Synapsin IIa.
   
 
 0.574
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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