node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
SDHB | nf1a | ENSDARP00000118231 | ENSDARP00000128480 | Si:dkey-31b16.7. | Neurofibromin 1a. | 0.582 |
SDHB | ret | ENSDARP00000118231 | ENSDARP00000072093 | Si:dkey-31b16.7. | Proto-oncogene tyrosine-protein kinase receptor Ret; Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation upon binding with glial cell derived neurotrophic factor family ligands. | 0.433 |
SDHB | sdha | ENSDARP00000118231 | ENSDARP00000018027 | Si:dkey-31b16.7. | Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial; Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q); Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily. | 0.999 |
SDHB | sdhaf2 | ENSDARP00000118231 | ENSDARP00000086049 | Si:dkey-31b16.7. | Succinate dehydrogenase assembly factor 2, mitochondrial; Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit sdha of the SDH catalytic dimer. | 0.890 |
SDHB | sdhaf3 | ENSDARP00000118231 | ENSDARP00000052395 | Si:dkey-31b16.7. | Succinate dehydrogenase assembly factor 3, mitochondrial; Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Promotes maturation of the iron-sulfur protein subunit sdhb of the SDH catalytic dimer, protecting it from the deleterious effects of oxidants. May act together with SDHAF1. | 0.861 |
SDHB | sdhc | ENSDARP00000118231 | ENSDARP00000121444 | Si:dkey-31b16.7. | Succinate dehydrogenase complex, subunit C, integral membrane protein. | 0.999 |
SDHB | sdhdb | ENSDARP00000118231 | ENSDARP00000039864 | Si:dkey-31b16.7. | Succinate dehydrogenase [ubiquinone] cytochrome b small subunit B, mitochondrial; Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q); Belongs to the CybS family. | 0.999 |
SDHB | tmem127 | ENSDARP00000118231 | ENSDARP00000045532 | Si:dkey-31b16.7. | Transmembrane protein 127; Controls cell proliferation acting as a negative regulator of TOR signaling pathway mediated by mTORC1; Belongs to the TMEM127 family. | 0.753 |
max | sdhaf2 | ENSDARP00000111552 | ENSDARP00000086049 | Protein max; Transcription regulator. Forms a sequence-specific DNA- binding protein complex with MYC or MAD which recognizes the core sequence 5'-CAC[GA]TG-3'. The MYC-MAX complex is a transcriptional activator, whereas the MAD-MAX complex is a repressor (By similarity). | Succinate dehydrogenase assembly factor 2, mitochondrial; Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit sdha of the SDH catalytic dimer. | 0.459 |
max | tmem127 | ENSDARP00000111552 | ENSDARP00000045532 | Protein max; Transcription regulator. Forms a sequence-specific DNA- binding protein complex with MYC or MAD which recognizes the core sequence 5'-CAC[GA]TG-3'. The MYC-MAX complex is a transcriptional activator, whereas the MAD-MAX complex is a repressor (By similarity). | Transmembrane protein 127; Controls cell proliferation acting as a negative regulator of TOR signaling pathway mediated by mTORC1; Belongs to the TMEM127 family. | 0.567 |
nf1a | SDHB | ENSDARP00000128480 | ENSDARP00000118231 | Neurofibromin 1a. | Si:dkey-31b16.7. | 0.582 |
nf1a | sdha | ENSDARP00000128480 | ENSDARP00000018027 | Neurofibromin 1a. | Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial; Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q); Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily. | 0.421 |
nf1a | sdhb | ENSDARP00000128480 | ENSDARP00000062263 | Neurofibromin 1a. | Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial; Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). | 0.581 |
nf1a | sdhc | ENSDARP00000128480 | ENSDARP00000121444 | Neurofibromin 1a. | Succinate dehydrogenase complex, subunit C, integral membrane protein. | 0.557 |
nf1a | sdhdb | ENSDARP00000128480 | ENSDARP00000039864 | Neurofibromin 1a. | Succinate dehydrogenase [ubiquinone] cytochrome b small subunit B, mitochondrial; Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q); Belongs to the CybS family. | 0.649 |
nf1a | tmem127 | ENSDARP00000128480 | ENSDARP00000045532 | Neurofibromin 1a. | Transmembrane protein 127; Controls cell proliferation acting as a negative regulator of TOR signaling pathway mediated by mTORC1; Belongs to the TMEM127 family. | 0.590 |
ret | SDHB | ENSDARP00000072093 | ENSDARP00000118231 | Proto-oncogene tyrosine-protein kinase receptor Ret; Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation upon binding with glial cell derived neurotrophic factor family ligands. | Si:dkey-31b16.7. | 0.433 |
ret | sdhaf3 | ENSDARP00000072093 | ENSDARP00000052395 | Proto-oncogene tyrosine-protein kinase receptor Ret; Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation upon binding with glial cell derived neurotrophic factor family ligands. | Succinate dehydrogenase assembly factor 3, mitochondrial; Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Promotes maturation of the iron-sulfur protein subunit sdhb of the SDH catalytic dimer, protecting it from the deleterious effects of oxidants. May act together with SDHAF1. | 0.558 |
ret | sdhb | ENSDARP00000072093 | ENSDARP00000062263 | Proto-oncogene tyrosine-protein kinase receptor Ret; Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation upon binding with glial cell derived neurotrophic factor family ligands. | Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial; Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). | 0.433 |
ret | sdhc | ENSDARP00000072093 | ENSDARP00000121444 | Proto-oncogene tyrosine-protein kinase receptor Ret; Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation upon binding with glial cell derived neurotrophic factor family ligands. | Succinate dehydrogenase complex, subunit C, integral membrane protein. | 0.557 |