Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
cyp27a7Cytochrome P450, family 27, subfamily A, polypeptide 7; Belongs to the cytochrome P450 family. (524 aa)    
Predicted Functional Partners:
cyp7a1
Cholesterol 7-alpha-monooxygenase; Belongs to the cytochrome P450 family.
  
 0.892
cyp7b1
Cytochrome P450, family 7, subfamily B, polypeptide 1; Belongs to the cytochrome P450 family.
    
 0.869
ch25hl1.2
Cholesterol 25-hydroxylase-like protein 1, member 2; May catalyze the formation of 25-hydroxycholesterol from cholesterol.
    
 0.836
sdcbp
Syndecan-binding protein (syntenin).
     
  0.830
dhcr24
24-dehydrocholesterol reductase.
    
 0.821
dhcr7
7-dehydrocholesterol reductase; Production of cholesterol by reduction of C7-C8 double bond of 7-dehydrocholesterol (7-DHC).
    
 0.820
ch25hl3
Cholesterol 25-hydroxylase-like 3; Belongs to the sterol desaturase family.
    
 0.814
lipf
Lipase; Belongs to the AB hydrolase superfamily. Lipase family.
   
  0.810
soat2
Sterol O-acyltransferase 2; Belongs to the membrane-bound acyltransferase family.
   
 
 0.809
cyp2r1
Cytochrome P450, family 2, subfamily R, polypeptide 1; Belongs to the cytochrome P450 family.
  
 
0.792
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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