Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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Assay-based Predictions
experimentally determined
co-expression
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gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
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plgPlasminogen; Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be modulated b [...] (818 aa)    
Predicted Functional Partners:
serpinf2b
Alpha-2-antiplasmin; Belongs to the serpin family.
   
 0.992
fgb
Fibrinogen, B beta polypeptide.
   
 
 0.987
fga
Fibrinogen alpha chain.
   
 
 0.985
serpinc1
Serine (Or cysteine) proteinase inhibitor, clade C (Antithrombin), member 1; Belongs to the serpin family.
   
 0.976
plat
Plasminogen activator; Belongs to the peptidase S1 family.
  
 
0.976
serpinf2a
Alpha-2-antiplasmin; Belongs to the serpin family.
   
 0.958
F2RL3
Si:ch211-132p1.2; Belongs to the G-protein coupled receptor 1 family.
    
 0.955
f2r
Coagulation factor II (thrombin) receptor; Belongs to the G-protein coupled receptor 1 family.
    
 0.948
f2
Coagulation factor II (thrombin); Belongs to the peptidase S1 family.
   
 
0.939
fgg
Fibrinogen, gamma polypeptide.
   
 
 0.938
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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