STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
wnt2bbProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (396 aa)    
Predicted Functional Partners:
fzd2
Frizzled class receptor 2; Belongs to the G-protein coupled receptor Fz/Smo family.
  
 
 0.845
sfrp5
Secreted frizzled-related protein 5.
    
 0.842
fzd5
Frizzled class receptor 5; Belongs to the G-protein coupled receptor Fz/Smo family.
    
 0.821
lrp5
Low density lipoprotein receptor-related protein 5.
   
 0.814
hhex
Hematopoietically-expressed homeobox protein hhex; Recognizes the DNA sequence 5'-ATTAA-3' (By similarity). Transcriptional repressor. Regulates the differentiation of both endothelial and blood cells. Plays a role in embryonic dorsoventral patterning by regulating bmp expression. May establish anterior identity. Functions in the embryo to regulate liver development. Functions extraembryonically to generate organ chirality.
   
  
 0.809
sfrp2
Secreted frizzled-related protein 2.
    
 0.806
sfrp1a
Secreted frizzled-related protein 1a.
    
 0.801
fzd1
Frizzled class receptor 1; Belongs to the G-protein coupled receptor Fz/Smo family.
  
 
 0.801
fzd7b
Frizzled class receptor 7b; Belongs to the G-protein coupled receptor Fz/Smo family.
  
 
 0.799
lrp6
Low density lipoprotein receptor-related protein 6.
    
 0.796
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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