Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
arl6ADP-ribosylation factor-like protein 6; Probably involved in membrane protein trafficking at the base of the ciliary organelle. May function in cilia biogenesis. Isoform 2 is required for proper retinal function and organization. Belongs to the small GTPase superfamily. Arf family. (186 aa)    
Predicted Functional Partners:
arl6ip1
ADP-ribosylation factor-like 6-interacting protein 1.
   
 
 0.851
bbs1
Bardet-Biedl syndrome 1.
   
 0.719
bbs7
Bardet-Biedl syndrome 7 protein homolog; The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function.
   
  0.695
bbs4
Bardet-Biedl syndrome 4.
   
  0.653
bbs2
Bardet-Biedl syndrome 2 protein homolog; Required for ciliogenesis.
    
  0.645
bbs5
Bardet-Biedl syndrome 5 protein homolog; Required for ciliogenesis; Belongs to the BBS5 family.
   
  0.597
bbip1
BBSome-interacting protein 1; Required for primary cilia assembly; Belongs to the BBIP10 family.
    
  0.564
gbf1
Golgi brefeldin A-resistant guanine nucleotide exchange factor 1.
    
 
 0.541
copb1
Coatomer subunit beta; The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin- coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins (By similarity).
   
 
 0.536
cyth4b
Cytohesin 4b.
    
 0.534
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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