Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
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mfsd2aaSodium-dependent lysophosphatidylcholine symporter 1-A; Sodium-dependent lysophosphatidylcholine (LPC) symporter, which plays an essential role for blood-brain barrier formation and function. Specifically expressed in endothelium of the blood-brain barrier of micro-vessels and transports LPC into the brain. Transport of LPC is essential because it constitutes the major mechanism by which docosahexaenoic acid (DHA), an omega-3 fatty acid that is essential for normal brain growth and cognitive function, enters the brain. Transports LPC carrying long-chain fatty acids such LPC oleate and [...] (532 aa)    
Predicted Functional Partners:
ZNF335
Si:ch211-269m15.3.
      
 0.734
slc2a1a
Facilitated glucose transporter 1; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
      
 0.683
lsr
Lipolysis-stimulated lipoprotein receptor.
      
 0.666
sass6
Spindle assembly abnormal protein 6 homolog; Central scaffolding component of the centrioles ensuring their 9-fold symmetry. Required for centrosome biogenesis and duplication: required both for mother-centriole- dependent centriole duplication and deuterosome-dependent centriole amplification in multiciliated cells (By similarity).
   
  
 0.659
cldn5a
Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.
      
 0.648
ncapd3
Condensin-2 complex subunit D3; Regulatory subunit of the condensin-2 complex, a complex which establishes mitotic chromosome architecture and is involved in physical rigidity of the chromatid axis.
      
 0.596
mfsd12a
Major facilitator superfamily domain-containing 12a.
      
 0.595
ndp
Norrin cystine knot growth factor NDP.
      
 0.594
map11
Microtubule-associated protein 11; Microtubule associated protein wich seems to play a role in spindle dynamics and cell division. Plays a role in brain cell proliferation.
      
 0.575
spns3
Protein spinster homolog 3; Sphingolipid transporter; Belongs to the major facilitator superfamily. Spinster (TC 2.A.1.49) family.
      
 0.561
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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