Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
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[Homology]
Score
pmelbPremelanosome protein b. (616 aa)    
Predicted Functional Partners:
tyrp1b
Tyrosinase-related protein 1b.
   
 
 0.785
tmem130
Transmembrane protein 130.
      
 0.760
slc24a5
Sodium/potassium/calcium exchanger 5; Cation exchanger which plays a central role in pigmentation, possibly by participating in ion transport in melanosomes. Probably transports 1 Ca(2+) and 1 K(+) in exchange for 4 Na(+). Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. SLC24A subfamily.
   
  
 0.724
dct
Dopachrome tautomerase.
   
 
 0.708
cax1
Type II CAX cation/proton exchanger; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family.
   
  
 0.683
tyrp1a
Tyrosinase-related protein 1a.
   
 
 0.635
mitfa
Microphthalmia-associated transcription factor a.
   
 
 0.624
mitfb
Microphthalmia-associated transcription factor b.
    
 
 0.622
tyr
Tyrosinase.
   
 
 0.619
dhrsx
Dehydrogenase/reductase (SDR family) X-linked.
    
 
 0.596
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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