Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
zgc:171445Zgc:171445 protein. (1459 aa)    
Predicted Functional Partners:
zgc:55888
Zgc:55888; Belongs to the peptidase S1 family.
   
  0.557
mmp2
Matrix metalloproteinase 2.
    
 0.553
mmp30
Matrix metallopeptidase 30.
    
 0.553
mmp20b
Matrix metallopeptidase 20b (enamelysin).
    
 0.553
mmp9
Matrix metallopeptidase 9.
    
 0.546
plg
Plasminogen; Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be modulated b [...]
   
 0.540
mmp13a
Matrix metallopeptidase 13a.
    
 0.510
mmp11a
Matrix metallopeptidase 11a.
    
 0.510
appa
Amyloid beta (A4) precursor protein a.
   
 0.487
ahsg2
Alpha-2-HS-glycoprotein 2.
   
 0.485
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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