Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
igf1rbTyrosine-protein kinase receptor. (1380 aa)    
Predicted Functional Partners:
ins
Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.
    
 0.980
insrb
Tyrosine-protein kinase receptor.
  
 
0.973
irs1
Insulin receptor substrate 1.
   
 0.970
igf2b
Insulin-like growth factor 2b.
    
 0.965
igf1
Insulin-like growth factor 1b.
     
 0.958
igf3
Insulin-like growth factor 3.
    
 0.958
mdm2
E3 ubiquitin-protein ligase Mdm2; E3 ubiquitin-protein ligase that mediates ubiquitination of p53/TP53, leading to its degradation by the proteasome.
    
 0.955
shc1
SHC (Src homology 2 domain-containing)-transforming protein 1.
    
 0.945
SHC3
SHC adaptor protein 3.
    
 0.945
irs4a
Insulin receptor substrate 4a.
    
 0.944
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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