node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ctnnb1 | igf1rb | ENSDARP00000139205 | ENSDARP00000046541 | Catenin beta-1; Key downstream component of the canonical Wnt signaling pathway (By similarity). In the absence of Wnt, forms a complex with axin1, axin2, apc, csnk1a1 and gsk3b that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of ctnnb1 and its subsequent degradation by the proteasome (By similarity). In the presence of Wnt ligand, ctnnb1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes (By similarity). Plays a key role in dorso [...] | Tyrosine-protein kinase receptor. | 0.944 |
ctnnb1 | ins | ENSDARP00000139205 | ENSDARP00000051221 | Catenin beta-1; Key downstream component of the canonical Wnt signaling pathway (By similarity). In the absence of Wnt, forms a complex with axin1, axin2, apc, csnk1a1 and gsk3b that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of ctnnb1 and its subsequent degradation by the proteasome (By similarity). In the presence of Wnt ligand, ctnnb1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes (By similarity). Plays a key role in dorso [...] | Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. | 0.763 |
ctnnb1 | insb | ENSDARP00000139205 | ENSDARP00000115146 | Catenin beta-1; Key downstream component of the canonical Wnt signaling pathway (By similarity). In the absence of Wnt, forms a complex with axin1, axin2, apc, csnk1a1 and gsk3b that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of ctnnb1 and its subsequent degradation by the proteasome (By similarity). In the presence of Wnt ligand, ctnnb1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes (By similarity). Plays a key role in dorso [...] | Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. | 0.763 |
ctnnb1 | irs1 | ENSDARP00000139205 | ENSDARP00000070706 | Catenin beta-1; Key downstream component of the canonical Wnt signaling pathway (By similarity). In the absence of Wnt, forms a complex with axin1, axin2, apc, csnk1a1 and gsk3b that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of ctnnb1 and its subsequent degradation by the proteasome (By similarity). In the presence of Wnt ligand, ctnnb1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes (By similarity). Plays a key role in dorso [...] | Insulin receptor substrate 1. | 0.411 |
grb10a | grb10b | ENSDARP00000115883 | ENSDARP00000122780 | Growth factor receptor-bound protein 10a. | Growth factor receptor-bound protein 10b. | 0.909 |
grb10a | igf1rb | ENSDARP00000115883 | ENSDARP00000046541 | Growth factor receptor-bound protein 10a. | Tyrosine-protein kinase receptor. | 0.954 |
grb10b | grb10a | ENSDARP00000122780 | ENSDARP00000115883 | Growth factor receptor-bound protein 10b. | Growth factor receptor-bound protein 10a. | 0.909 |
grb10b | igf1rb | ENSDARP00000122780 | ENSDARP00000046541 | Growth factor receptor-bound protein 10b. | Tyrosine-protein kinase receptor. | 0.947 |
grb10b | ins | ENSDARP00000122780 | ENSDARP00000051221 | Growth factor receptor-bound protein 10b. | Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. | 0.549 |
grb10b | irs1 | ENSDARP00000122780 | ENSDARP00000070706 | Growth factor receptor-bound protein 10b. | Insulin receptor substrate 1. | 0.466 |
grb10b | irs2b | ENSDARP00000122780 | ENSDARP00000136042 | Growth factor receptor-bound protein 10b. | Insulin receptor substrate 2b. | 0.465 |
igf1 | igf1rb | ENSDARP00000017449 | ENSDARP00000046541 | Insulin-like growth factor 1b. | Tyrosine-protein kinase receptor. | 0.979 |
igf1 | ins | ENSDARP00000017449 | ENSDARP00000051221 | Insulin-like growth factor 1b. | Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. | 0.979 |
igf1 | insb | ENSDARP00000017449 | ENSDARP00000115146 | Insulin-like growth factor 1b. | Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. | 0.926 |
igf1 | irs1 | ENSDARP00000017449 | ENSDARP00000070706 | Insulin-like growth factor 1b. | Insulin receptor substrate 1. | 0.569 |
igf1 | irs2b | ENSDARP00000017449 | ENSDARP00000136042 | Insulin-like growth factor 1b. | Insulin receptor substrate 2b. | 0.602 |
igf1 | irs4a | ENSDARP00000017449 | ENSDARP00000110181 | Insulin-like growth factor 1b. | Insulin receptor substrate 4a. | 0.499 |
igf1rb | ctnnb1 | ENSDARP00000046541 | ENSDARP00000139205 | Tyrosine-protein kinase receptor. | Catenin beta-1; Key downstream component of the canonical Wnt signaling pathway (By similarity). In the absence of Wnt, forms a complex with axin1, axin2, apc, csnk1a1 and gsk3b that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of ctnnb1 and its subsequent degradation by the proteasome (By similarity). In the presence of Wnt ligand, ctnnb1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes (By similarity). Plays a key role in dorso [...] | 0.944 |
igf1rb | grb10a | ENSDARP00000046541 | ENSDARP00000115883 | Tyrosine-protein kinase receptor. | Growth factor receptor-bound protein 10a. | 0.954 |
igf1rb | grb10b | ENSDARP00000046541 | ENSDARP00000122780 | Tyrosine-protein kinase receptor. | Growth factor receptor-bound protein 10b. | 0.947 |