| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| TXN | map2k6 | ENSDARP00000045696 | ENSDARP00000143278 | Thioredoxin; Belongs to the thioredoxin family. | Dual specificity mitogen-activated protein kinase kinase 6; Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in the MAP kinases p38 and plays an important role in the regulation of cellular responses to cytokines and all kinds of stresses. The p38 MAP kinase signal transduction pathway leads to direct activation of transcription factors. Phosphorylation by MAP2K6 asymmetrically activates p38 on one side of the blastodisc, an event which is n [...] | 0.528 |
| TXN | map3k5 | ENSDARP00000045696 | ENSDARP00000046640 | Thioredoxin; Belongs to the thioredoxin family. | Mitogen-activated protein kinase kinase kinase 5. | 0.987 |
| daxx | map3k5 | ENSDARP00000105452 | ENSDARP00000046640 | Death-domain-associated protein. | Mitogen-activated protein kinase kinase kinase 5. | 0.975 |
| ern2 | map3k5 | ENSDARP00000115811 | ENSDARP00000046640 | Endoplasmic reticulum to nucleus-signaling 2. | Mitogen-activated protein kinase kinase kinase 5. | 0.932 |
| ern2 | traf2a | ENSDARP00000115811 | ENSDARP00000043465 | Endoplasmic reticulum to nucleus-signaling 2. | TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. | 0.932 |
| ern2 | traf2b | ENSDARP00000115811 | ENSDARP00000144196 | Endoplasmic reticulum to nucleus-signaling 2. | TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. | 0.933 |
| map2k6 | TXN | ENSDARP00000143278 | ENSDARP00000045696 | Dual specificity mitogen-activated protein kinase kinase 6; Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in the MAP kinases p38 and plays an important role in the regulation of cellular responses to cytokines and all kinds of stresses. The p38 MAP kinase signal transduction pathway leads to direct activation of transcription factors. Phosphorylation by MAP2K6 asymmetrically activates p38 on one side of the blastodisc, an event which is n [...] | Thioredoxin; Belongs to the thioredoxin family. | 0.528 |
| map2k6 | map3k5 | ENSDARP00000143278 | ENSDARP00000046640 | Dual specificity mitogen-activated protein kinase kinase 6; Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in the MAP kinases p38 and plays an important role in the regulation of cellular responses to cytokines and all kinds of stresses. The p38 MAP kinase signal transduction pathway leads to direct activation of transcription factors. Phosphorylation by MAP2K6 asymmetrically activates p38 on one side of the blastodisc, an event which is n [...] | Mitogen-activated protein kinase kinase kinase 5. | 0.967 |
| map2k6 | mapk10 | ENSDARP00000143278 | ENSDARP00000134326 | Dual specificity mitogen-activated protein kinase kinase 6; Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in the MAP kinases p38 and plays an important role in the regulation of cellular responses to cytokines and all kinds of stresses. The p38 MAP kinase signal transduction pathway leads to direct activation of transcription factors. Phosphorylation by MAP2K6 asymmetrically activates p38 on one side of the blastodisc, an event which is n [...] | Mitogen-activated protein kinase. | 0.576 |
| map2k6 | mapk8b | ENSDARP00000143278 | ENSDARP00000012611 | Dual specificity mitogen-activated protein kinase kinase 6; Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in the MAP kinases p38 and plays an important role in the regulation of cellular responses to cytokines and all kinds of stresses. The p38 MAP kinase signal transduction pathway leads to direct activation of transcription factors. Phosphorylation by MAP2K6 asymmetrically activates p38 on one side of the blastodisc, an event which is n [...] | Mitogen-activated protein kinase 8; Responds to activation by environmental stress and pro- inflammatory cytokines by phosphorylating a number of transcription factors, primarily components of AP-1 such as c-Jun and ATF2 and thus regulates AP-1 transcriptional activity. May play a role in the regulation of the circadian clock. | 0.633 |
| map2k7 | map3k5 | ENSDARP00000048190 | ENSDARP00000046640 | Mitogen-activated protein kinase kinase 7. | Mitogen-activated protein kinase kinase kinase 5. | 0.932 |
| map2k7 | mapk10 | ENSDARP00000048190 | ENSDARP00000134326 | Mitogen-activated protein kinase kinase 7. | Mitogen-activated protein kinase. | 0.980 |
| map2k7 | mapk8b | ENSDARP00000048190 | ENSDARP00000012611 | Mitogen-activated protein kinase kinase 7. | Mitogen-activated protein kinase 8; Responds to activation by environmental stress and pro- inflammatory cytokines by phosphorylating a number of transcription factors, primarily components of AP-1 such as c-Jun and ATF2 and thus regulates AP-1 transcriptional activity. May play a role in the regulation of the circadian clock. | 0.979 |
| map3k5 | TXN | ENSDARP00000046640 | ENSDARP00000045696 | Mitogen-activated protein kinase kinase kinase 5. | Thioredoxin; Belongs to the thioredoxin family. | 0.987 |
| map3k5 | daxx | ENSDARP00000046640 | ENSDARP00000105452 | Mitogen-activated protein kinase kinase kinase 5. | Death-domain-associated protein. | 0.975 |
| map3k5 | ern2 | ENSDARP00000046640 | ENSDARP00000115811 | Mitogen-activated protein kinase kinase kinase 5. | Endoplasmic reticulum to nucleus-signaling 2. | 0.932 |
| map3k5 | map2k6 | ENSDARP00000046640 | ENSDARP00000143278 | Mitogen-activated protein kinase kinase kinase 5. | Dual specificity mitogen-activated protein kinase kinase 6; Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in the MAP kinases p38 and plays an important role in the regulation of cellular responses to cytokines and all kinds of stresses. The p38 MAP kinase signal transduction pathway leads to direct activation of transcription factors. Phosphorylation by MAP2K6 asymmetrically activates p38 on one side of the blastodisc, an event which is n [...] | 0.967 |
| map3k5 | map2k7 | ENSDARP00000046640 | ENSDARP00000048190 | Mitogen-activated protein kinase kinase kinase 5. | Mitogen-activated protein kinase kinase 7. | 0.932 |
| map3k5 | mapk10 | ENSDARP00000046640 | ENSDARP00000134326 | Mitogen-activated protein kinase kinase kinase 5. | Mitogen-activated protein kinase. | 0.935 |
| map3k5 | mapk8b | ENSDARP00000046640 | ENSDARP00000012611 | Mitogen-activated protein kinase kinase kinase 5. | Mitogen-activated protein kinase 8; Responds to activation by environmental stress and pro- inflammatory cytokines by phosphorylating a number of transcription factors, primarily components of AP-1 such as c-Jun and ATF2 and thus regulates AP-1 transcriptional activity. May play a role in the regulation of the circadian clock. | 0.929 |