Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
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Co-occurrence
Co-expression
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[Homology]
Score
clptm1Cleft lip and palate transmembrane protein 1 homolog; May play a role in T-cell development; Belongs to the CLPTM1 family. (631 aa)    
Predicted Functional Partners:
ddx11
ATP-dependent DNA helicase DDX11; DNA-dependent ATPase and ATP-dependent DNA helicase that participates in various functions in genomic stability, including DNA replication, DNA repair and heterochromatin organization as well as in ribosomal RNA synthesis. Plays a role in DNA double-strand break (DSB) repair at the DNA replication fork during DNA replication recovery from DNA damage. Plays a role in the regulation of sister chromatid cohesion and mitotic chromosome segregation. Stimulates 5'-single-stranded DNA flap endonuclease activity of FEN1 in an ATP- and helicase-independent mann [...]
    
 
 0.759
mad1l1
Mitotic arrest deficient-like protein 1.
    
 
 0.753
phgdh
D-3-phosphoglycerate dehydrogenase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.
   
 
 0.731
ENSDARP00000135683
Uncharacterized protein.
      
 0.711
nfatc2a
Nuclear factor of-activated T cells 2a.
      
 0.696
pdhb
Pyruvate dehydrogenase E1 component subunit beta; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.
     
 0.642
ncln
Nicalin-1; Antagonizes Nodal signaling and subsequent organization of axial structures during mesodermal patterning. Ectopic expression results in cyclopia, due to a defect in mesendoderm patterning. Belongs to the nicastrin family.
   
  
 0.632
mad2l1
MAD2 mitotic arrest deficient-like 1 (yeast).
    
   0.629
ENSDARP00000152227
HORMA domain-containing protein.
    
   0.629
smc3
Structural maintenance of chromosomes protein.
    
   0.627
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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