node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ccm2 | krit1 | ENSDARP00000022543 | ENSDARP00000138856 | Cerebral cavernous malformations protein 2 homolog; Component of the CCM signaling pathway which is a crucial regulator of heart and vessel formation and integrity. May act through the stabilization of endothelial cell junctions. May also function as a scaffold protein for MAP2K3-MAP3K3 signaling. Seems to play a major role in the modulation of MAP3K3-dependent p38 activation induced by hyperosmotic shock (By similarity). | Krev interaction trapped protein 1; Component of the CCM signaling pathway which is a crucial regulator of heart and vessel formation and integrity. Negative regulator of angiogenesis. Inhibits endothelial proliferation, apoptosis, migration, lumen formation and sprouting angiogenesis in primary endothelial cells. Plays a role in integrin signaling. Plays an important role in the maintenance of the intracellular reactive oxygen species (ROS) homeostasis to prevent oxidative cellular damage. Facilitates the down-regulation of cyclin-D1 (CCND1) levels required for cell transition from pr [...] | 0.999 |
ccm2 | pdcd10a | ENSDARP00000022543 | ENSDARP00000156496 | Cerebral cavernous malformations protein 2 homolog; Component of the CCM signaling pathway which is a crucial regulator of heart and vessel formation and integrity. May act through the stabilization of endothelial cell junctions. May also function as a scaffold protein for MAP2K3-MAP3K3 signaling. Seems to play a major role in the modulation of MAP3K3-dependent p38 activation induced by hyperosmotic shock (By similarity). | Programmed cell death protein 10-A; Promotes cell proliferation. Modulates apoptotic pathways. Increases mitogen-activated protein kinase activity. Important for cell migration, and for normal structure and assembly of the Golgi complex. Important for KDR/VEGFR2 signaling. Required for normal angiogenesis, vasculogenesis and hematopoiesis during embryonic development (By similarity). Required for normal cardiovascular development. | 0.995 |
ccm2 | stk25a | ENSDARP00000022543 | ENSDARP00000123777 | Cerebral cavernous malformations protein 2 homolog; Component of the CCM signaling pathway which is a crucial regulator of heart and vessel formation and integrity. May act through the stabilization of endothelial cell junctions. May also function as a scaffold protein for MAP2K3-MAP3K3 signaling. Seems to play a major role in the modulation of MAP3K3-dependent p38 activation induced by hyperosmotic shock (By similarity). | Serine/threonine kinase 25a. | 0.760 |
ccm2 | stk25b | ENSDARP00000022543 | ENSDARP00000056962 | Cerebral cavernous malformations protein 2 homolog; Component of the CCM signaling pathway which is a crucial regulator of heart and vessel formation and integrity. May act through the stabilization of endothelial cell junctions. May also function as a scaffold protein for MAP2K3-MAP3K3 signaling. Seems to play a major role in the modulation of MAP3K3-dependent p38 activation induced by hyperosmotic shock (By similarity). | Serine/threonine kinase 25 (STE20 homolog, yeast). | 0.652 |
ccm2 | stk26 | ENSDARP00000022543 | ENSDARP00000079474 | Cerebral cavernous malformations protein 2 homolog; Component of the CCM signaling pathway which is a crucial regulator of heart and vessel formation and integrity. May act through the stabilization of endothelial cell junctions. May also function as a scaffold protein for MAP2K3-MAP3K3 signaling. Seems to play a major role in the modulation of MAP3K3-dependent p38 activation induced by hyperosmotic shock (By similarity). | Serine/threonine protein kinase 26. | 0.593 |
ccm2l | krit1 | ENSDARP00000086332 | ENSDARP00000138856 | CCM2-like scaffold protein. | Krev interaction trapped protein 1; Component of the CCM signaling pathway which is a crucial regulator of heart and vessel formation and integrity. Negative regulator of angiogenesis. Inhibits endothelial proliferation, apoptosis, migration, lumen formation and sprouting angiogenesis in primary endothelial cells. Plays a role in integrin signaling. Plays an important role in the maintenance of the intracellular reactive oxygen species (ROS) homeostasis to prevent oxidative cellular damage. Facilitates the down-regulation of cyclin-D1 (CCND1) levels required for cell transition from pr [...] | 0.949 |
ccm2l | pdcd10a | ENSDARP00000086332 | ENSDARP00000156496 | CCM2-like scaffold protein. | Programmed cell death protein 10-A; Promotes cell proliferation. Modulates apoptotic pathways. Increases mitogen-activated protein kinase activity. Important for cell migration, and for normal structure and assembly of the Golgi complex. Important for KDR/VEGFR2 signaling. Required for normal angiogenesis, vasculogenesis and hematopoiesis during embryonic development (By similarity). Required for normal cardiovascular development. | 0.836 |
ccm2l | stk25b | ENSDARP00000086332 | ENSDARP00000056962 | CCM2-like scaffold protein. | Serine/threonine kinase 25 (STE20 homolog, yeast). | 0.404 |
ccm2l | stk26 | ENSDARP00000086332 | ENSDARP00000079474 | CCM2-like scaffold protein. | Serine/threonine protein kinase 26. | 0.450 |
cttnbp2nlb | mob4 | ENSDARP00000123484 | ENSDARP00000072975 | CTTNBP2 N-terminal-like b. | MOB1, Mps One Binder kinase activator-like 3 (Yeast). | 0.878 |
cttnbp2nlb | pdcd10a | ENSDARP00000123484 | ENSDARP00000156496 | CTTNBP2 N-terminal-like b. | Programmed cell death protein 10-A; Promotes cell proliferation. Modulates apoptotic pathways. Increases mitogen-activated protein kinase activity. Important for cell migration, and for normal structure and assembly of the Golgi complex. Important for KDR/VEGFR2 signaling. Required for normal angiogenesis, vasculogenesis and hematopoiesis during embryonic development (By similarity). Required for normal cardiovascular development. | 0.819 |
cttnbp2nlb | stk24b | ENSDARP00000123484 | ENSDARP00000135203 | CTTNBP2 N-terminal-like b. | Serine/threonine kinase 24b (STE20 homolog, yeast). | 0.580 |
cttnbp2nlb | stk25a | ENSDARP00000123484 | ENSDARP00000123777 | CTTNBP2 N-terminal-like b. | Serine/threonine kinase 25a. | 0.580 |
cttnbp2nlb | stk25b | ENSDARP00000123484 | ENSDARP00000056962 | CTTNBP2 N-terminal-like b. | Serine/threonine kinase 25 (STE20 homolog, yeast). | 0.580 |
cttnbp2nlb | stk26 | ENSDARP00000123484 | ENSDARP00000079474 | CTTNBP2 N-terminal-like b. | Serine/threonine protein kinase 26. | 0.607 |
krit1 | ccm2 | ENSDARP00000138856 | ENSDARP00000022543 | Krev interaction trapped protein 1; Component of the CCM signaling pathway which is a crucial regulator of heart and vessel formation and integrity. Negative regulator of angiogenesis. Inhibits endothelial proliferation, apoptosis, migration, lumen formation and sprouting angiogenesis in primary endothelial cells. Plays a role in integrin signaling. Plays an important role in the maintenance of the intracellular reactive oxygen species (ROS) homeostasis to prevent oxidative cellular damage. Facilitates the down-regulation of cyclin-D1 (CCND1) levels required for cell transition from pr [...] | Cerebral cavernous malformations protein 2 homolog; Component of the CCM signaling pathway which is a crucial regulator of heart and vessel formation and integrity. May act through the stabilization of endothelial cell junctions. May also function as a scaffold protein for MAP2K3-MAP3K3 signaling. Seems to play a major role in the modulation of MAP3K3-dependent p38 activation induced by hyperosmotic shock (By similarity). | 0.999 |
krit1 | ccm2l | ENSDARP00000138856 | ENSDARP00000086332 | Krev interaction trapped protein 1; Component of the CCM signaling pathway which is a crucial regulator of heart and vessel formation and integrity. Negative regulator of angiogenesis. Inhibits endothelial proliferation, apoptosis, migration, lumen formation and sprouting angiogenesis in primary endothelial cells. Plays a role in integrin signaling. Plays an important role in the maintenance of the intracellular reactive oxygen species (ROS) homeostasis to prevent oxidative cellular damage. Facilitates the down-regulation of cyclin-D1 (CCND1) levels required for cell transition from pr [...] | CCM2-like scaffold protein. | 0.949 |
krit1 | pdcd10a | ENSDARP00000138856 | ENSDARP00000156496 | Krev interaction trapped protein 1; Component of the CCM signaling pathway which is a crucial regulator of heart and vessel formation and integrity. Negative regulator of angiogenesis. Inhibits endothelial proliferation, apoptosis, migration, lumen formation and sprouting angiogenesis in primary endothelial cells. Plays a role in integrin signaling. Plays an important role in the maintenance of the intracellular reactive oxygen species (ROS) homeostasis to prevent oxidative cellular damage. Facilitates the down-regulation of cyclin-D1 (CCND1) levels required for cell transition from pr [...] | Programmed cell death protein 10-A; Promotes cell proliferation. Modulates apoptotic pathways. Increases mitogen-activated protein kinase activity. Important for cell migration, and for normal structure and assembly of the Golgi complex. Important for KDR/VEGFR2 signaling. Required for normal angiogenesis, vasculogenesis and hematopoiesis during embryonic development (By similarity). Required for normal cardiovascular development. | 0.983 |
krit1 | stk24b | ENSDARP00000138856 | ENSDARP00000135203 | Krev interaction trapped protein 1; Component of the CCM signaling pathway which is a crucial regulator of heart and vessel formation and integrity. Negative regulator of angiogenesis. Inhibits endothelial proliferation, apoptosis, migration, lumen formation and sprouting angiogenesis in primary endothelial cells. Plays a role in integrin signaling. Plays an important role in the maintenance of the intracellular reactive oxygen species (ROS) homeostasis to prevent oxidative cellular damage. Facilitates the down-regulation of cyclin-D1 (CCND1) levels required for cell transition from pr [...] | Serine/threonine kinase 24b (STE20 homolog, yeast). | 0.689 |
krit1 | stk25a | ENSDARP00000138856 | ENSDARP00000123777 | Krev interaction trapped protein 1; Component of the CCM signaling pathway which is a crucial regulator of heart and vessel formation and integrity. Negative regulator of angiogenesis. Inhibits endothelial proliferation, apoptosis, migration, lumen formation and sprouting angiogenesis in primary endothelial cells. Plays a role in integrin signaling. Plays an important role in the maintenance of the intracellular reactive oxygen species (ROS) homeostasis to prevent oxidative cellular damage. Facilitates the down-regulation of cyclin-D1 (CCND1) levels required for cell transition from pr [...] | Serine/threonine kinase 25a. | 0.737 |