STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
hmgb2aHigh mobility group box 2a. (213 aa)    
Predicted Functional Partners:
hmgb1a
High mobility group box 1a.
  
 
0.812
h1-0
H1 histone family, member 0.
   
 0.585
mfge8a
Milk fat globule-EGF factor 8 protein a.
    
 
 0.582
rsf1b.1
Remodeling and spacing factor 1b, tandem duplicate 1.
    
 
 0.575
nt5dc3
5'-nucleotidase domain-containing 3.
      
 0.570
tp53
Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of bax and fas antigen expression, or by repression of Bcl-2 expression.
   
 
 0.563
purab
Purine-rich element-binding protein Ab.
      
 0.562
zgc:110216
Zgc:110216.
   
 0.547
E7F5A4_DANRE
Si:dkey-261m9.12.
   
 0.545
E7FAK0_DANRE
Si:ch211-113a14.24.
   
 0.545
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.